ArticleThe EMBO journal1996
Gsh-1, an orphan Hox gene, is required for normal pituitary development.
Article in The EMBO journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed, 177 citations in OpenAlex.
- Ontogeny of the spinal cord dorsal horn.Science (New York, N.Y.) · 2026Article
- Dynamics of Cell Fate Decisions during Chemically Induced Multi-Lineage Trans-Differentiation at Single-Cell Level.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Control of tuberal hypothalamic development and its implications in metabolic disorders.Nature reviews. Endocrinology · 2025Review
- Transcriptional control of visual neural circuit development by GS homeobox 1.PLoS genetics · 2024Article
- Regulatory functions of homeobox domain transcription factors in fungi.Applied and environmental microbiology · 2024Review
- Gsx2, but not Gsx1, is necessary for early forebrain patterning and long-term survival in zebrafish.Developmental dynamics : an official publication of the American Association of Anatomists · 2023Article
- Single cell transcriptome analysis of developing arcuate nucleus neurons uncovers their key developmental regulators.Nature communications · 2019Article
- Distinct temporal requirements for Sonic hedgehog signaling in development of the tuberal hypothalamus.Development (Cambridge, England) · 2018Article
- Gsx transcription factors control neuronal versus glial specification in ventricular zone progenitors of the mouse lateral ganglionic eminence.Developmental biology · 2018Article
- Dlx1/2 and Otp coordinate the production of hypothalamic GHRH- and AgRP-neurons.Nature communications · 2018Article
- Single-Cell RNA-Seq of Mouse Dopaminergic Neurons Informs Candidate Gene Selection for Sporadic Parkinson Disease.American journal of human genetics · 2018Article
- Septal contributions to olfactory bulb interneuron diversity in the embryonic mouse telencephalon: role of the homeobox gene Gsx2.Neural development · 2017Article
- Development of the hypothalamus: conservation, modification and innovation.Development (Cambridge, England) · 2017Review
- The LIM-homeobox transcription factor Isl1 plays crucial roles in the development of multiple arcuate nucleus neurons.Development (Cambridge, England) · 2016Article
- ZBTB20 is required for anterior pituitary development and lactotrope specification.Nature communications · 2016Article
- Rbpj-κ mediated Notch signaling plays a critical role in development of hypothalamic Kisspeptin neurons.Developmental biology · 2015Article
- Gsx1 expression defines neurons required for prepulse inhibition.Molecular psychiatry · 2015Article
- Regionalized differentiation of CRH, TRH, and GHRH peptidergic neurons in the mouse hypothalamus.Brain structure & function · 2014Article
- Ontogenesis of peptidergic neurons within the genoarchitectonic map of the mouse hypothalamus.Frontiers in neuroanatomy · 2014Article
- Temporal identity transition from Purkinje cell progenitors to GABAergic interneuron progenitors in the cerebellum.Nature communications · 2014Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The anterior pituitary regulates the function of multiple organ systems as well as body growth, and in turn is controlled by peptides released by the hypothalamus. We find that mutation of the Gsh-1 homeobox gene results in pleiotropic effects on pituitary development and function. Homozygous mutants exhibit extreme dwarfism, sexual infantilism and significant perinatal mortality. The mutant pituitary is small in size and hypocellular, with severely reduced numbers of growth hormone- and prolactin-producing cells. Moreover, the pituitary content of a subset of pituitary hormones, including growth hormone, prolactin and luteinizing hormone, is significantly decreased. The hypothalamus, although morphologically normal, is also perturbed in mutants. The gsh-1 gene is shown to be essential for growth hormone-releasing hormone (GHRH) gene expression in the arcuate nucleus of the hypothalamus. Further, sequence and electrophoretic mobility shift data suggest the Gsh-1 and GHRH genes as potential targets regulated by the Gsh-1-encoded protein. The mutant phenotype indicates a critical role for Gsh-1 in the genetic hierarchy of the formation and function of the hypothalamic-pituitary axis.
Indexed as
Identifiers
8631293PMC450270W156202311What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.