ArticleMolecular and cellular biology1996
Role of EGR1 in regulation of stimulus-dependent CD44 transcription in B lymphocytes.
Article in Molecular and cellular biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Aging-associated autoimmunity in genetically diverse UM-HET3 mice shows an early female sex bias.GeroScience · 2026Article
- Expression of CD44 and Its Spliced Variants: Innate and Inducible Roles in Nervous Tissue Cells and Their Environment.International journal of molecular sciences · 2025Review
- Gemcitabine resistance of pancreatic cancer cells is mediated by IGF1R dependent upregulation of CD44 expression and isoform switching.Cell death & disease · 2022Article
- Early Growth Response Factor 1 in Aging Hematopoietic Stem Cells and Leukemia.Frontiers in cell and developmental biology · 2022Review
- Early growth response 1 (EGR1) activation in initial stages of host-pathogen interactions.Molecular biology reports · 2021Review
- Progress in the Application of Immune Checkpoint Inhibitor-Based Immunotherapy for Targeting Different Types of Colorectal Cancer.Frontiers in oncology · 2021Review
- Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy.Cell research · 2020Article
- Truncated Glioma-Associated Oncogene Homolog 1 (tGLI1) Mediates Mesenchymal Glioblastoma via Transcriptional Activation of CD44.Cancer research · 2018Article
- The biology and role of CD44 in cancer progression: therapeutic implications.Journal of hematology & oncology · 2018Review
- Targeting Cancer Stem Cells in Castration-Resistant Prostate Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2016Article
- Targeting early B-cell receptor signaling induces apoptosis in leukemic mantle cell lymphoma.Experimental hematology & oncology · 2013Article
- Early growth response 3 (Egr3) is highly over-expressed in non-relapsing prostate cancer but not in relapsing prostate cancer.PloS one · 2013Article
- Carabin deficiency in B cells increases BCR-TLR9 costimulation-induced autoimmunity.EMBO molecular medicine · 2012Article
- Primary mesenchymal stem and progenitor cells from bone marrow lack expression of CD44 protein.The Journal of biological chemistry · 2012Article
- Article
- B cell signature during inactive systemic lupus is heterogeneous: toward a biological dissection of lupus.PloS one · 2011Article
- Tumor-initiating cells are enriched in CD44(hi) population in murine salivary gland tumor.PloS one · 2011Article
- HGF-promoted motility in primary human melanocytes depends on CD44v6 regulated via NF-kappa B, Egr-1, and C/EBP-beta.The Journal of investigative dermatology · 2010Article
- Hyaluronan promotes the chondrocyte response to BMP-7.Osteoarthritis and cartilage · 2009Article
- Early growth response genes regulate B cell development, proliferation, and immune response.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The immediate-early gene egr-1 encodes a transcription factor (EGR1) that links B-cell antigen receptor (BCR) signals to downstream activation events through the regulation of previously unidentified target genes. Here we identify the gene encoding the lymphocyte homing and migration protein CD44 as a target of EGR1 regulation in B cells. BCR-induced increases in CD44 mRNA expression and transcription levels are shown to occur in EGR1-expressing but not in nonexpressing subclones of the B-cell line WEHI-231. Kinetics of egr-1 transcription and the appearance of nuclear EGR1 protein precede CD44 induction and occur within 30 min after stimulation in the EGR1-expressing subclone. A single EGR1 binding motif is demonstrated at bp -301 of the human CD44 promoter. Cotransfection of a CD44 promoter-chloramphenicol acetyltransferase reporter construct with an egr-1 expression vector resulted in a 6.5- to 8.5-fold induction of transcriptional activity relative to an empty expression vector. The EGR1 binding motif was shown to be necessary for stimulus-induced expression of a CD44 promoter-chloramphenicol acetyltransferase reporter construct in nontransformed B lymphocytes and was required for transactivation by an EGR1 expression vector in a B-cell line. These studies identify EGR1 as an intermediary linking BCR-derived signals to the induction of CD44. The relevance of these molecular events to BCR signal transduction and antigen-stimulated B-cell-mediated immune responses is discussed.
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