ArticleMolecular and cellular biology1996
The E2F transcription factor activates a replication-dependent human H2A gene in early S phase of the cell cycle.
Article in Molecular and cellular biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 56 citations in OpenAlex.
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- High-affinity Rb binding, p53 inhibition, subcellular localization, and transformation by wild-type or tumor-derived shortened Merkel cell polyomavirus large T antigens.Journal of virology · 2014Article
- Multilayered chromatin analysis reveals E2f, Smad and Zfx as transcriptional regulators of histones.Nature structural & molecular biology · 2013Article
- Genome-wide analysis of regions similar to promoters of histone genes.BMC systems biology · 2010Article
- Arabidopsis gene co-expression network and its functional modules.BMC bioinformatics · 2009Article
- Constitutive expression exposes functional redundancy between the Arabidopsis histone H2A gene HTA1 and other H2A gene family members.The Plant cell · 2006Article
- Multiple independent evolutionary solutions to core histone gene regulation.Genome biology · 2006Article
- Comparative analysis of expression of histone H2a genes in mouse.BMC genomics · 2005Article
- Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7.The Biochemical journal · 2003Article
- NPAT expression is regulated by E2F and is essential for cell cycle progression.Molecular and cellular biology · 2003Article
- Regulation of E2F1-dependent gene transcription and apoptosis by the ETS-related transcription factor GABPgamma1.Molecular and cellular biology · 2002Article
- Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis.Genes & development · 2002Article
- p300 acts as a transcriptional coactivator for mammalian Notch-1.Molecular and cellular biology · 2001Article
- NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription.Genes & development · 2000Article
- Dysregulation of cyclin E gene expression in human cytomegalovirus-infected cells requires viral early gene expression and is associated with changes in the Rb-related protein p130.Journal of virology · 2000Article
- Cell cycle control, checkpoint mechanisms, and genotoxic stress.Environmental health perspectives · 1999Review
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Histone gene expression is restricted to the S phase of the cell cycle. Control is mediated by a complex network of sequence-specific DNA-binding factors and protein-protein interactions in response to cell cycle progression. To further investigate the regulatory functions that are associated at the transcriptional level, we analyzed the regulation of a replication-dependent human H2A.1-H2B.2 gene pair. We found that transcription factor E2F binds specifically to an E2F recognition motif in the H2A.1 promoter region. Activation of the H2A.1 promoter by E2F-1 was shown by use of luciferase reporter constructs of the intergenic promoter region. Overexpression of the human retinoblastoma suppressor gene product RB suppressed E2F-1 mediated transcriptional activation, indicating an E2F-dependent regulation of promoter activity during the G1-to-S-phase transition. Furthermore, the activity of the H2A.1 promoter was also downregulated by overexpression of the RB-related p107, a protein that has been detected in S-phase-specific protein complexes of cyclin A, E2F, and cdk2. In synchronized HeLa cells, expression of luciferase activity was induced at the beginning of DNA synthesis and was dependent on the presence of an E2F-binding site in the H2A.1 promoter. Together with the finding that E2F-binding motifs are highly conserved in H2A promoters of other species, our results suggest that E2F plays an important role in the coordinate regulation of S-phase-specific histone gene expression.
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