ArticleMolecular & general genetics : MGG1996
Molecular analysis of the scrA and scrB genes from Klebsiella pneumoniae and plasmid pUR400, which encode the sucrose transport protein Enzyme II Scr of the phosphotransferase system and a sucrose-6-phosphate invertase.
Article in Molecular & general genetics : MGG, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- Acarbose differentially affects gut microbial metabolism of maltose and sucrose, distinctly modulating host metabolism.iScience · 2026Article
- Antibacterial Activities of Phenolic Compounds inAntibiotics (Basel, Switzerland) · 2024Article
- The Scr and Csc pathways for sucrose utilization co-exist inFrontiers in microbiology · 2024Article
- Expression and characterization of a β-fructofuranosidase from the parasitic protist Trichomonas vaginalis.BMC biochemistry · 2014Article
- Catabolism of raffinose, sucrose, and melibiose in Erwinia chrysanthemi 3937.Journal of bacteriology · 2009Article
- How to become a uropathogen: comparative genomic analysis of extraintestinal pathogenic Escherichia coli strains.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Comparative genomic analyses of the bacterial phosphotransferase system.Microbiology and molecular biology reviews : MMBR · 2005Review
- Molecular and functional characterization of a unique sucrose hydrolase from Xanthomonas axonopodis pv. glycines.Journal of bacteriology · 2004Article
- Adaptation of sucrose metabolism in the Escherichia coli wild-type strain EC3132.Journal of bacteriology · 2002Article
- Molecular analysis of sucrose metabolism of Erwinia amylovora and influence on bacterial virulence.Journal of bacteriology · 2000Article
- Characterization of the divergent sacBK and sacAR operons, involved in sucrose utilization by Lactococcus lactis.Journal of bacteriology · 1999Article
- Culture of the causative organism of donovanosis (Calymmatobacterium granulomatis) in HEp-2 cells.Journal of clinical microbiology · 1997Article
- CTnscr94, a conjugative transposon found in enterobacteria.Journal of bacteriology · 1997Article
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Klebsiella pneumoniae genes scrA and scrB are indispensable for sucrose (Scr) utilisation. Gene scrA codes for an Enzyme IIScr (IIScr) transport protein of the phosphoenolpyruvate-dependent carbohydrate: phosphotransferase system (PTS), while scrB encodes a sucrose 6-phosphate specific invertase. A 3.7 kbscr AB DNA fragment has been cloned from K. pneumoniae and expressed in Escherichia coli. Its nucleotide sequence was determined and the coding regions for scrA (1371 bp) and scrB (1401 bp) were identified by genetic complementation, enzyme activity test and radiolabelling of the gene products. In addition, the nucleotide sequence of the scrB gene from conjugative plasmid pUR400 isolated from Salmonella typhimurium was also determined and errors in the previously published sequence of the scrA gene of pUR400 were corrected. Extensive similarity was found between the sequences of ScrA and other Enzymes II, as well as between the two invertases and other sucrose hydrolysing enzymes. Based on the analysis of seven IIScr proteins, a hypothetical model of the secondary structure of IIScr is proposed.
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