ArticleJournal of virology1996
Developmental analysis of the cytomegalovirus enhancer in transgenic animals.
Article in Journal of virology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 74 citations in OpenAlex.
- Ubiquitin ligase RNF146 coordinates bone dynamics and energy metabolism.The Journal of clinical investigation · 2017Article
- Viral enhancer mimicry of host innate-immune promoters.PLoS pathogens · 2014Review
- Article
- The activator protein 1 binding motifs within the human cytomegalovirus major immediate-early enhancer are functionally redundant and act in a cooperative manner with the NF-{kappa}B sites during acute infection.Journal of virology · 2011Article
- In vivo competence of murine cytomegalovirus under the control of the human cytomegalovirus major immediate-early enhancer in the establishment of latency and reactivation.Journal of virology · 2008Article
- Translational mini-review series on infectious disease: congenital cytomegalovirus infection: 50 years on.Clinical and experimental immunology · 2007Review
- Murine cytomegalovirus major immediate-early enhancer region operating as a genetic switch in bidirectional gene pair transcription.Journal of virology · 2007Article
- Hepatomegaly in transgenic mice expressing the homeobox gene Cux-1.Molecular carcinogenesis · 2005Article
- Making better transgenic models: conditional, temporal, and spatial approaches.Molecular biotechnology · 2005Review
- An enhancer-trap LacZ transgene reveals a distinct expression pattern of Kinesin family 26B in mouse embryos.Development genes and evolution · 2004Article
- An essential role of the enhancer for murine cytomegalovirus in vivo growth and pathogenesis.Journal of virology · 2003Article
- Cre-mediated germline mosaicism: a new transgenic mouse for the selective removal of residual markers from tri-lox conditional alleles.Nucleic acids research · 2003Article
- The transgenic ICP4 promoter is activated in Schwann cells in trigeminal ganglia of mice latently infected with herpes simplex virus type 1.Journal of virology · 2001Article
- Tet-system for the regulation of gene expression during embryonic development.Transgenic research · 2001Article
- Kinetics of recombinant adeno-associated virus-mediated gene transfer.Journal of virology · 2000Article
- Identification of a boundary domain adjacent to the potent human cytomegalovirus enhancer that represses transcription of the divergent UL127 promoter.Journal of virology · 2000Article
- The human cytomegalovirus major immediate-early distal enhancer region is required for efficient viral replication and immediate-early gene expression.Journal of virology · 2000Article
- Principles of homeostasis in governing virus activation and latency.Immunologic research · 2000Review
- In vivo replication of recombinant murine cytomegalovirus driven by the paralogous major immediate-early promoter-enhancer of human cytomegalovirus.Journal of virology · 1999Article
- Murine cytomegalovirus immediate-early promoter directs astrocyte-specific expression in transgenic mice.The American journal of pathology · 1999Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
The major immediate-early promoter (MIEP) of human, cytomegalovirus (HCMV) constitutes a primary genetic switch for viral activation. In this study, regulation of the enhancer-containing segment (nucleotides -670 to +54) of the HCMV MIEP attached to the 1acZ reporter gene was examined in the developing embryos of transgenic mice to identify temporal and tissue-specific expression. We find that the transgene reporter is first detected as a dorsal stripe of expression in the neural folds of embryos at day 8.5 postcoitum (p.c.). A broad expression pattern is exhibited in embryos at day 9.5 p.c. This pattern becomes more restricted by day 10.5 p.c. as organogenesis progresses. By day 14.5 p.c., prominent expression is observed in a subpopulation of central nervous system cells and spinal ganglia, endothelial cells, muscle, skin, thyroid, parathyroid, kidney, lung, liver, and gut cells, and the pancreas and submandibular and pituitary glands. This distribution pattern is discussed in relation to human congenital HCMV infection. These results suggest that the transcriptional activity of the HCMV MIEP may determine in part, the ability of the virus to specifically target developing fetal tissues in utero.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.