Evidence map›Paper›PMID 8627773›Full record

ArticleJournal of virology1996

Intracellular posttranslational modifications of S1133 avian reovirus proteins.

R Varela, J Martínez-Costas, M Mallo, J Benavente

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in Journal of virology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Oncotarget · 2018
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  13. Genomic characterization of a turkey reovirus field strain by Next-Generation Sequencing.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2015
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Crystallization of the avian reovirus double-stranded RNA-binding and core protein sigmaA.Acta crystallographica. Section F, Structural biology and crystallization communications · 2007
    Article
  19. Crystallization of the C-terminal globular domain of avian reovirus fibre.Acta crystallographica. Section F, Structural biology and crystallization communications · 2005
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

R VarelaDepartamento de Bioquímica y Biologia Molecular, Facultad de Farmacia, Santiago de Compostela, Spain.
J Martínez-Costas
M Mallo
J Benavente
Universidade de Santiago de Compostela · ESMax Planck Society · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Avian reovirus S1133 specifies at least 10 primary translation products, eight of which are present in the viral particle and two of which are nonstructural proteins. In the work presented here, we studied the covalent modifications undergone by these translation products in the infected cell. The structural polypeptide mu2 was shown to be intracellularly modified by both myristoylation and proteolysis. The site-specific cleavage of mu2 yielded a large carboxy-terminal fragment and a myristoylated approximately 5,500-Mr peptide corresponding to the amino terminus. Both mu2 and its cleavage products were found to be structural components of the reovirion. Most avian reovirus proteins were found to be glycosylated and to have a blocking group at the amino terminus. In contrast to the mammalian reovirus system, none of the avian reovirus polypeptides was found to incorporate phosphorus during infection. Our results add to current understanding of the similarities and differences between avian and mammalian reoviruses.

Indexed as

Protein Processing, Post-TranslationalAmino Acid SequenceAnimalsCells, CulturedChick EmbryoElectrophoresis, Polyacrylamide GelFibroblastsMethionineMolecular Sequence DataMolecular WeightMyristic AcidMyristic AcidsOrthoreovirusPeptide FragmentsPeptide MappingProtein BiosynthesisMethionineMyristic AcidMyristic AcidsPeptide FragmentsSulfur RadioisotopesViral ProteinsViral Structural Proteins

Identifiers

PMID8627773
PMCPMC190156
OpenAlexW1953927534

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.