ArticleJournal of virology1996
Frequent perinatal transmission of feline immunodeficiency virus by chronically infected cats.
Article in Journal of virology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 96 citations in OpenAlex.
- Feline immunodeficiency virus: current insights into pathogenesis, clinical impact, and advances in treatment and vaccine development.Frontiers in veterinary science · 2025Review
- Reproductive Management in Catteries: Optimising health and wellbeing through veterinarian-breeder collaboration.Journal of feline medicine and surgery · 2022Review
- Concomitant feline immunodeficiency virus (FIV) andThe Canadian veterinary journal = La revue veterinaire canadienne · 2018Article
- Seroprevalence of feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV) in shelter cats on the island of Newfoundland, Canada.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2014Article
- Natural transmission of feline immunodeficiency virus from infected queen to kitten.Virology journal · 2012Article
- Viral reproductive pathogens of dogs and cats.The Veterinary clinics of North America. Small animal practice · 2012Review
- Review
- Feline leukemia virus and feline immunodeficiency virus in Canada: recommendations for testing and management.The Canadian veterinary journal = La revue veterinaire canadienne · 2011Review
- Immunomodulator expression in trophoblasts from the feline immunodeficiency virus (FIV)-infected cat.Virology journal · 2011Article
- Cytokine dysregulation in early- and late-term placentas from feline immunodeficiency virus (FIV)-infected cats.American journal of reproductive immunology (New York, N.Y. : 1989) · 2011Article
- Article
- Prior mucosal exposure to heterologous cells alters the pathogenesis of cell-associated mucosal feline immunodeficiency virus challenge.Retrovirology · 2010Article
- Placental immunopathology in the FIV-infected cat: a role for inflammation in compromised pregnancy?Veterinary immunology and immunopathology · 2010Review
- Feline immunodeficiency virus (FIV) as a model for study of lentivirus infections: parallels with HIV.Current HIV research · 2010Review
- Feline immunodeficiency virus model for designing HIV/AIDS vaccines.Current HIV research · 2010Review
- Magnetic resonance imaging of radiation-induced thymic atrophy as a model for pathologic changes in acute feline immunodeficiency virus infection.Journal of feline medicine and surgery · 2009Article
- Improved health and survival of FIV-infected cats is associated with the presence of autoantibodies to the primary receptor, CD134.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Maternal hematological and virological characteristics during early feline immunodeficiency virus (FIV) infection of cats as predictors of fetal infection and reproductive outcome at early gestation.Veterinary immunology and immunopathology · 2009Article
- Feline immunodeficiency. ABCD guidelines on prevention and management.Journal of feline medicine and surgery · 2009Review
- Canine and feline pregnancy loss due to viral and non-infectious causes: a review.Theriogenology · 2008Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Vertical transmission of feline immunodeficiency virus (FIV) was studied in cats infected with either of two FIV clinical isolates (FIV-B-2542 or FIV-AB-2771) prior to breeding and conception. Queens infected 4 to 30 months (mean = 14 months) prior to conception transmitted FIV to 59 of 83 (71%) kittens; 50.6% were virus positive on the day of birth. To examine potential routes of FIV transmission from mother to offspring, kittens were delivered via either vaginal or cesarean birth and nursed by either their virus-infected natural mothers or uninfected surrogate mothers. Comparison of FIV infection rates at birth with those at 6 months of age in kittens delivered by cesarean and surrogate raised demonstrated that late in utero transmission occurred in approximately 20% of kittens. Comparison of kittens nursed by FIV mothers with those by uninfected surrogate mothers demonstrated a 13.5% increase in infection rate of kittens exposed to milk-borne virus. Isolation of virus from 40% of maternal vaginal wash samples and the slightly greater infection rate in vaginally versus cesarean-delivered surrogate-nursed kittens suggested that intrapartum transmission may occur. In addition, we found that low maternal CD4 count (<200 cells per microl), longer duration of maternal infection (>15 months), and maternal symptoms of clinical immunodeficiency correlated with increased rates of mother-to-kitten FIV transmission, paralleling observations in human immunodeficiency virus-infected women. We conclude that FIV infection provides a model in which to explore aspects of human immunodeficiency virus vertical transmission and intervention difficult to address in human patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.