ArticleJournal of virology1996
Improvement of retroviral retargeting by using amino acid spacers between an additional binding domain and the N terminus of Moloney murine leukemia virus SU.
Article in Journal of virology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 81 citations in OpenAlex.
- Cell type-specific delivery by modular envelope design.Nature communications · 2023Article
- Targeting lentiviral vectors to primordial germ cells (PGCs): An efficient strategy for generating transgenic chickens.Zoological research · 2020Article
- Analysis of two monoclonal antibodies reactive with envelope proteins of murine retroviruses: one pan specific antibody and one specific for Moloney leukemia virus.Journal of virological methods · 2014Article
- Targeted entry via somatostatin receptors using a novel modified retrovirus glycoprotein that delivers genes at levels comparable to those of wild-type viral glycoproteins.Journal of virology · 2012Article
- Vectors for the treatment of autoimmune disease.Gene therapy · 2003Review
- Redirecting retroviral tropism by insertion of short, nondisruptive peptide ligands into envelope.Journal of virology · 2002Article
- Two point mutations produce infectious retrovirus bearing a green fluorescent protein-SU fusion protein.Journal of virology · 2001Article
- Antibody-directed targeting of retroviral vectors via cell surface antigens.Journal of virology · 2001Article
- Role of chimeric murine leukemia virus env beta-turn polyproline spacers in receptor cooperation.Journal of virology · 2001Article
- Evidence for nonspecific adsorption of targeted retrovirus vector particles to cells.Gene therapy · 2001Article
- Functional characterization of the N termini of murine leukemia virus envelope proteins.Journal of virology · 2001Article
- A TVA-single-chain antibody fusion protein mediates specific targeting of a subgroup A avian leukosis virus vector to cells expressing a tumor-specific form of epidermal growth factor receptor.Journal of virology · 2000Article
- Retroviral vectors preloaded with a viral receptor-ligand bridge protein are targeted to specific cell types.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Retrovirus targeting by tropism restriction to melanoma cells.Journal of virology · 1999Article
- Antigen-specific membrane fusion mediated by the haemagglutinin protein of influenza A virus: separation of attachment and fusion functions on different molecules.Gene therapy · 1999Article
- Cell-type-specific gene transfer into human cells with retroviral vectors that display single-chain antibodies.Journal of virology · 1998Article
- Cell-specific viral targeting mediated by a soluble retroviral receptor-ligand fusion protein.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Incorporation of fowl plague virus hemagglutinin into murine leukemia virus particles and analysis of the infectivity of the pseudotyped retroviruses.Journal of virology · 1998Article
- Definition of a 14-amino-acid peptide essential for the interaction between the murine leukemia virus amphotropic envelope glycoprotein and its receptor.Journal of virology · 1998Article
- Variable regions A and B in the envelope glycoproteins of feline leukemia virus subgroup B and amphotropic murine leukemia virus interact with discrete receptor domains.Journal of virology · 1997Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We previously reported a strategy to redirect the retroviral host range by expressing single-chain antibodies (S. J. Russell, R. E. Hawkins, and G. Winter, Nucleic Acids Res. 21:1081-1085, 1993) or ligands (F.-L. Cosset, F. J Morling, Y. Takeuchi, R. A. Weiss, M. K. L. Collins, and S. J. Russell, J. Virol. 69:6314-6322, 1995) at the N terminus of Moloney murine leukemia virus (MoMLV) surface proteins (SU). Although such chimeric envelopes were able to bind the new receptors, the transduction efficiency of retargeted viruses was generally low. We hypothesized that conformational rearrangements of envelope glycoproteins were not optimally triggered following binding, and to overcome these postbinding blocks, we have generated here a set of chimeric MoMLV-derived envelopes targeted to the Ram-1 phosphate transporter in which we have varied the spacing between the Ram-1-binding domain and the MoMLV SU. All of the recombinant envelopes were correctly expressed on virions, and all bound efficiently to Ram-1. However, the interdomain spacing greatly affected the efficiency of gene transfer by retroviral vectors that had bound to Ram-1 via their chimeric envelopes. Optimal interdomain spacing allowed a 100-fold-increased viral transduction via Ram-1 compared to our previous results.
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