ArticleJournal of virology1996
Predominant involvement of CD8+CD28- lymphocytes in human immunodeficiency virus-specific cytotoxic activity.
Article in Journal of virology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Who cites it
25 citing papers in PubMed.
- Expression of CD28 and CD38 by CD8+ T lymphocytes in HIV-1 infection correlates with markers of disease severity and changes towards normalization under treatment. The Swiss HIV Cohort Study.Clinical and experimental immunology · 1999Trial
- Abnormal glucose and lipid metabolism promotes disrupted differentiation of T and B cell subsets in Behçet's disease.Immunotherapy advances · 2025Article
- Cytolytic CD4Frontiers in immunology · 2022Review
- CD28 and CD57 define four populations with distinct phenotypic properties within human CD8European journal of immunology · 2020Article
- Human CD8+ T Cells in Asthma: Possible Pathways and Roles for NK-Like Subtypes.Frontiers in immunology · 2016Review
- Mesenchymal stem cells control alloreactive CD8(+) CD28(-) T cells.Clinical and experimental immunology · 2013Article
- Review
- Dynamics of T cell memory in human cytomegalovirus infection.Medical microbiology and immunology · 2008Review
- Analysis of CD28 and bcl-2 expression on peripheral blood and liver-infiltrating mononuclear cells in patients with autoimmune hepatitis.Journal of clinical immunology · 2006Article
- Inflammatory process of CD8+ CD28- T cells in induced sputum from asthmatic patients.Mediators of inflammation · 2005Article
- CD8beta/CD28 expression defines functionally distinct populations of peripheral blood T lymphocytes.Clinical and experimental immunology · 2003Article
- Correlates of immune activation marker changes in human immunodeficiency virus (HIV)-seropositive and high-risk HIV-seronegative women who use illicit drugs.The Journal of infectious diseases · 2003Article
- Article
- Enhanced interferon-gamma by CD8+ CD28- lymphocytes from HIV+ patients.Journal of clinical immunology · 2001Article
- HIV infection and aging: enhanced Interferon- and Tumor Necrosis Factor-alpha production by the CD8+ CD28- T subset.BMC immunology · 2001Article
- Human immunodeficiency virus type 1 induces apoptosis in CD4(+) but not in CD8(+) T cells in ex vivo-infected human lymphoid tissue.Journal of virology · 2000Article
- Anti-human immunodeficiency virus type 1 (HIV-1) CD8(+) T-lymphocyte reactivity during combination antiretroviral therapy in HIV-1-infected patients with advanced immunodeficiency.Journal of virology · 2000Article
- Weak anti-HIV CD8(+) T-cell effector activity in HIV primary infection.The Journal of clinical investigation · 1999Article
- Comparative analysis of cytotoxic T lymphocytes in lymph nodes and peripheral blood of simian immunodeficiency virus-infected rhesus monkeys.Journal of virology · 1999Article
- Expression of adhesion molecules and CD28 on T lymphocytes during human immunodeficiency virus infection.Clinical and diagnostic laboratory immunology · 1998Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Distinct functional CD8+ T-cell populations have been observed during human immunodeficiency virus (HIV) infection. One of these functions is the inhibition of viral replication by a noncytotoxic mechanism, which was shown to be mediated by the CD8+CD28+ subpopulation. On the other hand, CD8+ T cells exert an HIV-specific cytotoxic activity. The present study shows that CD8+CD28- lymphocytes display this HIV-specific cytotoxic activity, which is detectable immediately after the cells are purified from peripheral blood. The CD28- population is also able to proliferate and to retain its cytotoxic activity after in vitro restimulation with autologous blast cells. Finally, HIV-specific cytotoxic T cells can be obtained in vitro from the CD8+CD28+ population.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.