ArticleJournal of virology1996
Identification of a herpesvirus Saimiri cis-acting DNA fragment that permits stable replication of episomes in transformed T cells.
Article in Journal of virology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- The replisome pausing factor Timeless is required for episomal maintenance of latent Epstein-Barr virus.Journal of virology · 2011Article
- Horizontal gene transfers with or without cell fusions in all categories of the living matter.Advances in experimental medicine and biology · 2011Review
- An autonomous replicating element within the KSHV genome.Cell host & microbe · 2007Article
- Recombinant bovine herpesvirus 4 (BoHV-4) expressing glycoprotein D of BoHV-1 is immunogenic and elicits serum-neutralizing antibodies against BoHV-1 in a rabbit model.Clinical and vaccine immunology : CVI · 2006Article
- Bovine herpesvirus 4 infects differentiated neuronal cells in culture and establish persistent infection upon selection.Journal of neurovirology · 2004Article
- Selective gene expression of latent murine gammaherpesvirus 68 in B lymphocytes.Journal of virology · 2003Article
- The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus supports latent DNA replication in dividing cells.Journal of virology · 2002Article
- Coupling of mitotic chromosome tethering and replication competence in epstein-barr virus-based plasmids.Molecular and cellular biology · 2001Article
- Herpesvirus saimiri.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2001Review
- Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 mediates episome persistence through cis-acting terminal repeat (TR) sequence and specifically binds TR DNA.Journal of virology · 2001Article
- Evolutionary aspects of oncogenic herpesviruses.Molecular pathology : MP · 2000Review
- Analysis of gene expression in a human cell line stably transduced with herpesvirus saimiri.Journal of virology · 2000Article
- Genetic evidence that EBNA-1 is needed for efficient, stable latent infection by Epstein-Barr virus.Journal of virology · 1999Article
- Primary structure of the alcelaphine herpesvirus 1 genome.Journal of virology · 1997Article
- Functional phenotype of transformed human alphabeta and gammadelta T cells determined by different subgroup C strains of herpesvirus Saimiri.Journal of virology · 1997Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Herpesvirus saimiri is a lymphotropic herpesvirus capable of immortalizing and transforming T cells both in vitro and in vivo. Immortalized and transformed T cells harbor several copies of the viral genome as a persisting genome. The mapping of the cis-acting genetic cis-acting segment (oriP) required for viral episomal maintenance is reported here. Viral DNA fragments that potentially contain oriP were cloned into a plasmid that contains the hygromycin resistance gene. After several round of subcloning followed by transfection, oriP was mapped to a 1.955-kb viral segment. This viral fragment permits stable plasmid replication without deletion or rearrangement as well as episomal maintenance without integration or recombination. The function of oriP depends on a trans-acting factor(s) encoded by the viral genome. The 1.955-kb viral segment includes a dyad symmetry region located between two small nuclear RNA genes and is located upstream of the dihydrofolate reductase gene homolog. Therefore, this oriP contains novel elements distinct from those of other DNA viruses.
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