ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1996
Transgenic expression of embryonic MAP2 in adult mouse brain: implications for neuronal polarization.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 35 citations in OpenAlex.
- Ischemic tolerance in an in vivo model of glutamate preconditioning.Journal of neuroscience research · 2015Article
- Mitotic impairment by doublecortin is diminished by doublecortin mutations found in patients.Neurogenetics · 2004Article
- The role of microtubule-associated protein 2c in the reorganization of microtubules and lamellipodia during neurite initiation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Cytoskeletal microdifferentiation: a mechanism for organizing morphological plasticity in dendrites.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Identification of a cis-acting dendritic targeting element in MAP2 mRNAs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Making sense of the multiple MAP-2 transcripts and their role in the neuron.Molecular neurobiology · 1998Review
- Sorting of beta-actin mRNA and protein to neurites and growth cones in culture.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Differential intracellular sorting of immediate early gene mRNAs depends on signals in the mRNA sequence.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Isoform specificity in the relationship of actin to dendritic spines.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The major neuronal microtubule-associated protein MAP2 is selectively localized in dendrites, where its expression is under strong developmental regulation. To learn more about its potential effects on neuronal morphogenesis and its sorting within the neuronal cytoplasm, we have raised transgenic mice that express high levels of the embryonic form, MAP2c, in the adult brain. One transgenic line expressed higher levels of MAP2c than endogenous adult MAP2. This had no detectable effect on either the arrangement or morphology of neurons, suggesting that although MAP2c is necessary for neuronal morphogenesis it is not involved in its regulation. Like endogenous adult MAP2, transgenic MAP2c was present in dendrites but not axons, indicating that the signal responsible for its cytoplasmic sorting is contained within the 1.5 kb of its coding sequence. In situ hybridization with specific probes showed that transgenic MAP2c mRNA was limited to cell bodies. Thus, the dendritic localization of MAP2c protein cannot be the result of previous transport of its mRNA but must depend on a signal associated with the protein itself. Furthermore, because the amino acid sequence of MAP2c is present in all forms of MAP2, this signal is also contained within adult high-M(r) MAP2 protein. This raises the possibility that, rather than the conventional scheme of mRNA sorting preceding protein localization, the transport of adult MAP2 mRNA into dendrites could depend on it being part of a translation complex in which the targeting signal is on the nascent protein.
Indexed as
Identifiers
8627364PMC6579129W1558179348What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.