ArticleThe Journal of experimental medicine1996
Aod2, the locus controlling development of atrophy in neonatal thymectomy-induced autoimmune ovarian dysgenesis, co-localizes with Il2, Fgfb, and Idd3.
Article in The Journal of experimental medicine, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 49 citations in OpenAlex.
- T Regulatory Cells From Non-obese Diabetic Mice Show Low Responsiveness to IL-2 Stimulation and Exhibit Differential Expression of Anergy-Related and Ubiquitination Factors.Frontiers in immunology · 2019Article
- A T cell extrinsic mechanism by which IL-2 dampens Th17 differentiation.Journal of autoimmunity · 2015Article
- Forward genetic approaches for elucidation of novel regulators of Lyme arthritis severity.Frontiers in cellular and infection microbiology · 2014Review
- Endocrine autoimmune diseases and female infertility.Nature reviews. Endocrinology · 2014Review
- Regulatory T cells control tolerogenic versus autoimmune response to sperm in vasectomy.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- The postnatal maternal environment affects autoimmune disease susceptibility in A/J mice.Cellular immunology · 2010Article
- A single nucleotide polymorphism in Tyk2 controls susceptibility to experimental allergic encephalomyelitis.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Cutting edge: the Idd3 genetic interval determines regulatory T cell function through CD11b+CD11c- APC.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- The IL-2/CD25 pathway determines susceptibility to T1D in humans and NOD mice.Journal of clinical immunology · 2008Article
- Commonality in the genetic control of Type 1 diabetes in humans and NOD mice: variants of genes in the IL-2 pathway are associated with autoimmune diabetes in both species.Biochemical Society transactions · 2008Review
- SNPs upstream of the minimal promoter control IL-2 expression and are candidates for the autoimmune disease-susceptibility locus Aod2/Idd3/Eae3.Genes and immunity · 2008Article
- Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.Nature genetics · 2007Article
- Autoimmune orchitis, epididymitis, and vasitis are immunogenetically distinct lesions.The American journal of pathology · 1998Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
In genetically susceptible strains of mice, such as A/J and (C57BL/6J x A/J)F1 hybrids, neonatal thymectomy-induced autoimmune ovarian dysgenesis (AOD) is characterized by the development of antiovarian autoantibodies, oophoritis, and atrophy. Temporally, atrophy may be observed during and after the regression of inflammatory infiltrates from the ovary. Histologically, lesions appear as areas devoid of ovarian follicles in all stages of development that have been replaced by luteinized interstitial cells. We report here the mapping of Aod2, the locus that controls this phenotype, to mouse chromosomes 3 within a region encoding Il2 and Fgfb. Most significant, however, is the co-localization of Aod2 to Idd3, a susceptibility gene that plays a role in autoimmune insulin-dependent type 1 diabetes mellitus in the nonobese diabetic mouse.
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