ArticleThe Journal of experimental medicine1996
Recurrent T cell receptor rearrangements in the cytotoxic T lymphocyte response in vivo against the p815 murine tumor.
Article in The Journal of experimental medicine, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Sharing of T cell receptors in antigen-specific responses is driven by convergent recombination.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Mouse models of efficient and inefficient anti-tumor immunity, with emphasis on minimal residual disease and tumor escape.Cancer immunology, immunotherapy : CII · 2006Review
- T-cell clonotypes in cancer.Journal of translational medicine · 2004Article
- Conserved T cell receptor usage in primary and recall responses to an immunodominant influenza virus nucleoprotein epitope.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- T cell receptor gene rearrangement lineage analysis reveals clues for the origin of highly restricted antigen-specific repertoires.The Journal of experimental medicine · 2003Article
- Prevalence of an ulcerative colitis-associated CD8+ T cell receptor beta-chain CDR3-region motif and its association with disease activity.Journal of clinical immunology · 2001Article
- T cell immunity in neonates.Immunologic research · 2000Review
- Murine natural killer T(NKT) cells [correction of natural killer cells] contribute to the granulomatous reaction caused by mycobacterial cell walls.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Cytotoxic T lymphocytes to an unmutated tumor rejection antigen P1A: normal development but restrained effector function in vivo.The Journal of experimental medicine · 1999Article
- Conserved T cell receptor repertoire in primary and memory CD8 T cell responses to an acute viral infection.The Journal of experimental medicine · 1998Article
- Quantitative analysis of the T cell repertoire selected by a single peptide-major histocompatibility complex.The Journal of experimental medicine · 1998Article
- Cytolytic T lymphocyte responses of cancer patients to tumor-associated antigens.Springer seminars in immunopathology · 1996Review
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Authors and funding
5 authors.
Funding
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Abstract
P815 is a murine mastocytoma of DBA/2 origin which, although immunogenic, rapidly develops as a tumor in immunocompetent syngeneic hosts. In this report, we have studied, by a molecular approach, the in vivo alpha/beta T cell response to P815. Both situations of tumor growth after engraftment of naive animals or tumor rejection by preimmunized animals have been analyzed. The spectrum of T cell receptor beta chain rearrangements in the tumor-infiltrating lymphocytes was found to be highly variable among individual tumor-bearing mice. However, two rearrangements, one using V(beta)1 and J(beta)1.2 segments and one using the V(beta)1 and J(beta)2.5 segments, with conserved junctional regions, reproducibly emerge in most individuals. These two rearrangements thus correspond to "public" (recurrent) T cell clones, as opposed to "private" ones, which emerge in a seemingly stochastic fashion in immunized animals. Importantly, these public cells are observed in situations of either growth or rejection of the tumor. Quantification provides a clear increase in public T cells in secondary responses, but no obvious correlation provides between their level and primary tumor rejection. The V(beta)1- J(beta)1.2 rearrangement is borne by CTL directed against an antigen derived from P1A, a nonmutated mouse self protein which is expressed in P815 but not in normal mouse tissues except testis. A recurrent, public T cell response can thus be observed to an antigen derived from a self protein expressed by a tumor.
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