ArticleThe Journal of experimental medicine1996
Peripheral T cells undergoing superantigen-induced apoptosis in vivo express B220 and upregulate Fas and Fas ligand.
Article in The Journal of experimental medicine, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 136 citations in OpenAlex.
- Role of T cells in liver metastasis.Cell death & disease · 2024Review
- Are superantigens the cause of cytokine storm and viral sepsis in severe COVID-19? Observations and hypothesis.Scandinavian journal of immunology · 2020Article
- Selective Host Cell Death byFrontiers in immunology · 2020Review
- Variations in Cellular Responses of Mouse T Cells to Adenosine-5'-Triphosphate Stimulation Do Not Depend on P2X7 Receptor Expression Levels but on Their Activation and Differentiation Stage.Frontiers in immunology · 2018Article
- Incidence of spontaneous lymphomas in non-experimental NOD/Shi-scid, IL-2RγExperimental animals · 2017Article
- A20 Curtails Primary but Augments Secondary CD8Scientific reports · 2016Article
- Sensitivity of leukemic T-cell lines to arsenic trioxide cytotoxicity is dependent on the induction of phosphatase B220/CD45R expression at the cell surface.Molecular cancer · 2014Article
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- Superantigens increase the survival of mice bearing T cell lymphomas by inducing apoptosis of neoplastic cells.PloS one · 2010Article
- Antigen-Experienced CD4lo T Cells Are Linked to Deficient Contraction of the Immune Response in Autoimmune Diabetes.Autoimmune diseases · 2010Article
- CD95, BIM and T cell homeostasis.Nature reviews. Immunology · 2009Review
- Review
- Mutation in the Fas pathway impairs CD8+ T cell memory.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Apoptosis regulators Fas and Bim cooperate in shutdown of chronic immune responses and prevention of autoimmunity.Immunity · 2008Article
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- Circulating gamma delta T cells in response to Salmonella enterica serovar enteritidis exposure in chickens.Infection and immunity · 2006Article
- Life and death of lymphocytes: a role in immunesenescence.Immunity & ageing : I & A · 2005Article
- Regulation of lymphocyte apoptosis by interferon regulatory factor 4 (IRF-4).The Journal of experimental medicine · 2003Article
- Partial tolerance of subcutaneously transplanted xenogeneic tumour cell graft by Fas-mediated immunosuppression.Immunology · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Staphylococcal enterotoxin B (SEB) is a bacterial superantigen (SAg) that predominantly interacts with V(beta)8+ T cells. In vivo treatment of mice with SEB leads to an initial increase in the percentage of V(beta)8+ T cells, followed by a decrease in the numbers of these cells, eventually reaching lower levels than those found before treatment with the SAg. This decrease is due to apoptosis of the SEB-responding cells. In the present study, we use the distinct light scattering characteristics of apoptotic cells to characterize T cells that are being deleted in response to SEB in vivo. We show that dying, SEB-reactive T cells express high levels of Fas and Fas ligand (Fas-L), which are implicated in apoptotic cell death. In addition, the B cell marker B220 is upregulated on apoptotic cells. Moreover, we show that the generation of cells with an apoptotic phenotype is severely impaired in response to SEB in functional Fas-L-deficient mutant gld mice, confirming the role of the Fas pathway in SAg mediated peripheral deletion in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.