ArticleJournal of bacteriology1996
Erwinia amylovora secretes harpin via a type III pathway and contains a homolog of yopN of Yersinia spp.
Article in Journal of bacteriology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 107 citations in OpenAlex.
- Molecular Targets and Strategies for Inhibition of the Bacterial Type III Secretion System (T3SS); Inhibitors Directly Binding to T3SS Components.Biomolecules · 2021Review
- TheFrontiers in plant science · 2020Article
- Fire blight host-pathogen interaction: proteome profiles of Erwinia amylovora infecting apple rootstocks.Scientific reports · 2018Article
- The type III secretion system is necessary for the development of a pathogenic and endophytic interaction between Herbaspirillum rubrisubalbicans and Poaceae.BMC microbiology · 2012Article
- HopX1 in Erwinia amylovora functions as an avirulence protein in apple and is regulated by HrpL.Journal of bacteriology · 2012Article
- HrpN of Erwinia amylovora functions in the translocation of DspA/E into plant cells.Molecular plant pathology · 2008Article
- The hrpN gene of Erwinia amylovora stimulates tobacco growth and enhances resistance to Botrytis cinerea.Planta · 2006Article
- Autoinduction in Erwinia amylovora: evidence of an acyl-homoserine lactone signal in the fire blight pathogen.Journal of bacteriology · 2005Article
- Process of protein transport by the type III secretion system.Microbiology and molecular biology reviews : MMBR · 2004Review
- Nucleotide sequences, genetic organization, and distribution of pEU30 and pEL60 from Erwinia amylovora.Applied and environmental microbiology · 2004Article
- Comparison of ATPase-encoding type III secretion system hrcN genes in biocontrol fluorescent Pseudomonads and in phytopathogenic proteobacteria.Applied and environmental microbiology · 2004Article
- Characterization of the hrp pathogenicity cluster of Erwinia carotovora subsp. carotovora: high basal level expression in a mutant is associated with reduced virulence.Molecular genetics and genomics : MGG · 2003Article
- The EspD protein of enterohemorrhagic Escherichia coli is required for the formation of bacterial surface appendages and is incorporated in the cytoplasmic membranes of target cells.Infection and immunity · 1999Article
- The Xanthomonas Hrp type III system secretes proteins from plant and mammalian bacterial pathogens.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- The virulence plasmid of Yersinia, an antihost genome.Microbiology and molecular biology reviews : MMBR · 1998Review
- Contact-dependent protein secretion in Porphyromonas gingivalis.Infection and immunity · 1998Article
- HrpW of Erwinia amylovora, a new harpin that contains a domain homologous to pectate lyases of a distinct class.Journal of bacteriology · 1998Article
- Pas, a novel protein required for protein secretion and attaching and effacing activities of enterohemorrhagic Escherichia coli.Journal of bacteriology · 1998Article
- Characterization of the hrpC and hrpRS operons of Pseudomonas syringae pathovars syringae, tomato, and glycinea and analysis of the ability of hrpF, hrpG, hrcC, hrpT, and hrpV mutants to elicit the hypersensitive response and disease in plants.Journal of bacteriology · 1998Article
- A cloned Erwinia chrysanthemi Hrp (type III protein secretion) system functions in Escherichia coli to deliver Pseudomonas syringae Avr signals to plant cells and to secrete Avr proteins in culture.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type III secretion functions in flagellar biosynthesis and in export of virulence factors from several animal pathogens, and for plant pathogens, it has been shown to be involved in the export of elicitors of the hypersensitive reaction. Typified by the Yop delivery system of Yersinia spp., type III secretion is sec independent and requires multiple components. Sequence analysis of an 11.5-kb region of the hrp gene cluster of Erwinia amylovora containing hrpI, a previously characterized type III gene, revealed a group of eight or more type III genes corresponding to the virB or lcrB (yscN-to-yscU) locus of Yersinia spp. A homolog of another Yop secretion gene, yscD, was found between hrpI and this group downstream. Immediately upstream of hrpI, a homolog of yopN was discovered. yopN is a putative sensor involved in host-cell-contact-triggered expression and transfer of protein, e.g., YopE, to the host cytoplasm. In-frame deletion mutagenesis of one of the type III genes, designated hrcT, was nonpolar and resulted in a Hrp- strain that produced but did not secrete harpin, an elicitor of the hypersensitive reaction that is also required for pathogenesis. Cladistic analysis of the HrpI (herein renamed HrcV) or LcrD protein family revealed two distinct groups for plant pathogens. The Yersinia protein grouped more closely with the plant pathogen homologs than with homologs from other animal pathogens; flagellar biosynthesis proteins grouped distinctly. A possible evolutionary history of type III secretion is presented, and the potential significance of the similarity between the harpin and Yop export systems is discussed, particularly with respect to a potential role for the YopN homolog in pathogenesis of plants.
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