Evidence map›Paper›PMID 8625752›Full record

ArticleDigestive diseases and sciences1996

Gallbladder cancer. A comparative study among clinicopathologic features, AgNORs, and DNA content analysis.

J E Nishizawa-Takano, H Ayabe, K Hatano, H Yamaguchi, Y Tagawa

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Digestive diseases and sciences, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

J E Nishizawa-TakanoFirst Department of Surgery, Nagasaki University School of Medicine, Japan.
H Ayabe
K Hatano
H Yamaguchi
Y Tagawa
Nagasaki University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A comparative study among clinicopathologic features, silver-stained nucleolar organizer region associated proteins (AgNORs), and DNA content analysis in 76 patients with gallbladder cancer was performed. The AgNOR count, AgNOR area, and the ration of AgNOR area to nuclear area were significantly higher in patients with a low grade of histological differentiation and deep invasion into the gallbladder wall. Moreover, these parameters were higher in cases with lymph node involvement and distant metastases. DNA ploidy pattern and clinicopathologic features showed to statistical significance. Our results demonstrate that AgNOR parameters are useful indicators to evaluate the malignant behavior of gallbladder cancer. Furthermore, the AgNOR count together with the depth of the neoplastic invasion and lymph node metastases proved to be independent prognostic factors for survival in patients with gallbladder cancer.

Indexed as

AdultAgedAged, 80 and overAnalysis of VarianceDNA, NeoplasmFemaleFlow CytometryGallbladderGallbladder NeoplasmsHumansLymphatic MetastasisMaleMiddle AgedNeoplasm InvasivenessNucleolus Organizer RegionPloidiesDNA, Neoplasm

Identifiers

PMID8625752
OpenAlexW2058610136

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.