Evidence map›Paper›PMID 8625735›Full record

ReviewChromosoma1996

Transcription and masking of mRNA in germ cells: involvement of Y-box proteins.

J Sommerville, M Ladomery

Abstract readReview
PubMed Publisher
In one paragraph

Review in Chromosoma, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 63 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Lampbrush chromosomes and associated bodies: new insights into principles of nuclear structure and function.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2002
    Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

J SommervilleSchool of Biological and Medical Sciences, University of St Andrews, Bute Medical Buildings, St. Andrews, Fife, KY16 9TS, Scotland.
M Ladomery
University of St Andrews · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

Gametogenesis is directed by various specialized genetic mechanisms which, to a considerable extent, apply to the production of both eggs and sperm and have been conserved across a wide spectrum of eukaryotic organisms. Two key aspects which are discussed here are: germ-cell-specific gene transcription; and translational repression (masking) of mRNA accumulated in oocytes and spermatocytes/spermatids. Together, these two processes conspire to deliver often large amounts of essential proteins at the appropriate stages of development. It is perhaps not surprising that recent evidence points to a functional link between transcription activation and translation repression, both processes being determined in the nucleus and involving common components. One set of components which has been studied recently are members of the Y-box family of regulatory proteins. Most information of the involvement of Y-box proteins in germ cell development comes from studies on amphibian oocytes and mammalian spermatids. In these cells, Y-box proteins have been detected as major components of both maternal and paternal mRNP particles and have been shown to be instrumental in the masking process. Y-box proteins are also implicated in the regulation of several germ-cell-specific genes. Possible connections between these processes are discussed.

Indexed as

Gene Expression Regulation, DevelopmentalTranscription, GeneticXenopus ProteinsAmino Acid SequenceAnimalsBase SequenceEgg ProteinsGerm CellsHeterogeneous-Nuclear RibonucleoproteinsMolecular Sequence DataMultigene FamilyPromoter Regions, GeneticProtein BiosynthesisRibonucleoproteinsRNA-Binding ProteinsRNA, MessengerEgg ProteinsHeterogeneous-Nuclear RibonucleoproteinsRibonucleoproteinsRNA-Binding ProteinsRNA, MessengerTranscription FactorsXenopus ProteinsYBX2 protein, Xenopus

Identifiers

PMID8625735
OpenAlexW2009483317

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.