ArticleThe American journal of pathology1996
Normal human ovary and ovarian tumors express glycodelin, a glycoprotein with immunosuppressive and contraceptive properties.
Article in The American journal of pathology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 72 citations in OpenAlex.
- Silencing progestagen-associated endometrial protein (PAEP) suppresses sorafenib resistance and enhances sorafenib-induced ferroptosis in hepatocellular carcinoma.Liver research (Beijing, China) · 2026Article
- Is neonatal uterine bleeding responsible for early-onset endometriosis?Reproductive biology and endocrinology : RB&E · 2023Article
- Pathways regulating the expression of the immunomodulatory protein glycodelin in non‑small cell lung cancer.International journal of oncology · 2019Article
- Recent Advances in Identifying Biomarkers and High-Affinity Aptamers for Gynecologic Cancers Diagnosis and Therapy.Journal of analytical methods in chemistry · 2019Review
- Higher follicular fluid glycodelin levels are negatively correlated with embryonic development in assisted reproduction.JBRA assisted reproduction · 2018Article
- The Roles of Glycodelin in Cancer Development and Progression.Frontiers in immunology · 2017Review
- Increased expression of glycodelin mRNA and protein in rat lungs during ovalbumin-induced allergic airway inflammation.Histochemistry and cell biology · 2009Article
- Immunohistochemistry, glycosylation and immunosuppression of glycodelin in human ovarian cancer.Histochemistry and cell biology · 2009Article
- Discrimination between serous low malignant potential and invasive epithelial ovarian tumors using molecular profiling.Oncogene · 2005Article
- Immunolocalization of glycodelin in the genital tract of rats.Journal of molecular histology · 2005Article
- Characterization of monoclonal antibodies to glycodelin and recombinant glycodelin.The Histochemical journal · 2000Article
- alpha2-macroglobulin modulates the immunoregulatory function of the lipocalin placental protein 14.The Biochemical journal · 2000Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glycodelin is a glycoprotein with potent immunosuppressive and contraceptive activities. It reacts with antibodies against placental protein 14, or progesterone-associated endometrial protein, and has a unique carbohydrate structure. Previous nomenclature is misleading, because glycodelin is neither synthesized in the placenta nor is it endometrium specific. No ovarian synthesis of glycodelin has been demonstrated. We present evidence for glycodelin synthesis in the human ovary and ovarian tumors. In follicular phase, immunoperoxidase staining of microwave-treated tissue sections employing affinity-purified polyclonal antibodies localized glycodelin to areas of stromal cell condensation in ovarian cortex, theca interna, and the granulosa. In luteal phase, cortical stroma was negative or only weakly positive, whereas glycodelin was present in theca interna of the corpus luteum and luteinized granulosa cells and also in corpus albicans and Leydig cells of the ovarian hilus. In situ hybridization gave negative results for glycodelin mRNA in normal ovary, whereas in ovarian tumors strong expression of both the glycodelin mRNA and the protein were found in benign and malignant serous cystadenomas, mucinous ovarian tumors being negative. We conclude that glycodelin is synthesized in human ovarian tumors, and its occurrence in normal human ovary may represent either synthesis or a site of glycodelin action.
Indexed as
Identifiers
8623915PMC1861557W991872155What OpenQuestion holds
Registered trials
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