ArticleThe American journal of pathology1996
CD40 antigen is expressed by endothelial cells and tumor cells in Kaposi's sarcoma.
Article in The American journal of pathology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 65 citations in OpenAlex.
- Candidate Biomarkers for Specific Intraoperative Near-Infrared Imaging of Soft Tissue Sarcomas: A Systematic Review.Cancers · 2021Review
- Pathology analysis of a rare case of diffuse pulmonary lymphangiomatosis.Annals of translational medicine · 2016Article
- Kaposin-B enhances the PROX1 mRNA stability during lymphatic reprogramming of vascular endothelial cells by Kaposi's sarcoma herpes virus.PLoS pathogens · 2010Article
- Giving blood: a new role for CD40 in tumorigenesis.The Journal of experimental medicine · 2006Article
- Triggering CD40 on endothelial cells contributes to tumor growth.The Journal of experimental medicine · 2006Article
- Human immunodeficiency virus (HIV) type 1 Vpu induces the expression of CD40 in endothelial cells and regulates HIV-induced adhesion of B-lymphoma cells.Journal of virology · 2004Article
- Manipulation of glycogen-synthase kinase-3 activity in KSHV-associated cancers.Journal of molecular medicine (Berlin, Germany) · 2004Review
- Proliferation and apoptosis in the evolution of endemic and acquired immunodeficiency syndrome-related Kaposi's sarcoma.Medical oncology (Northwood, London, England) · 2000Article
- Cyclin D1 expression and HHV8 in Kaposi sarcoma.Journal of clinical pathology · 1999Article
- Inducible nitric oxide synthase (iNOS) expression may predict distant metastasis in human melanoma.British journal of cancer · 1999Article
- CD40 upregulation is independent of HHV-8 in the pathogenesis of Kaposi's sarcoma.Molecular pathology : MP · 1999Article
- Human keratinocytes express cellular prion-related protein in vitro and during inflammatory skin diseases.The American journal of pathology · 1998Article
- HHV8 and Kaposi's sarcoma: a time cohort study.Molecular pathology : MP · 1997Article
- Kaposi's sarcoma associated herpes virus (KSHV/HHV 8): epidemiology, molecular biology and tissue distribution.Molecular pathology : MP · 1997Review
- Charting a new course through the chaos of KS (Kaposi's sarcoma)The American journal of pathology · 1996Review
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The CD40 antigen is a member of the tumor necrosis factor receptor/nerve growth factor receptor superfamily and is involved in cell proliferation, differentiation, and survival. Using different monoclonal antibodies, we found CD40 expression by immunohistochemistry on CD31- and CD34-positive Kaposi's sarcoma spindle cells in all tumors of 18 HIV-1 seropositive and 4 HIV-1 seronegative patients. Western blot analysis of tumor lysates detected a 48- to 50-kd glycoprotein corresponding to the CD40 antigen expressed by B lymphocytes. CD40 expression was also detectable in one of four cultures of spindle cells derived from Kaposi sarcoma tissue. Treatment of the CD40-positive spindle cells but not of the CD40-negative ones with interferon-gamma up-regulated CD40 surface expression. Besides on Kaposi sarcoma tumor cells, CD40 was distinctly present on vascular endothelial cells in areas within and adjacent to the tumors and in benign inflammatory lesions such as granulation tissue of HIV-1-negative patients. In contrast, CD34-negative endothelia of thin walled vessels, most likely lymphatics, were predominantly CD40 negative. Only faint or no CD40 expression was found on endothelial cells in normal skin. We conclude from our data that expression of the CD40 antigen by endothelial cells is up-regulated during tissue inflammation. As signaling through CD40 is able to increase cell survival, expression of CD40 by Kaposi sarcoma tumor cells might play an important role in the pathogenesis of this neoplasm.
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8623911PMC1861578W306685850What OpenQuestion holds
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