ArticleProceedings of the National Academy of Sciences of the United States of America1996
Transcription of the human corticotropin-releasing hormone gene in NPLC cells is correlated with Z-DNA formation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 65 citations in OpenAlex.
- Triplexes Color the Chromaverse by Modulating Nucleosome Phasing and Anchoring Chromatin Condensates.International journal of molecular sciences · 2025Review
- Global identification and functional characterization of Z-DNA in rice.Plant biotechnology journal · 2025Article
- Z-DNA and Z-RNA: Methods-Past and Future.Methods in molecular biology (Clifton, N.J.) · 2023Article
- ChIP-Seq Strategy to Identify Z-DNA-Forming Sequences in the Human Genome.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Sequence-dependent cost for Z-form shapes the torsion-driven B-Z transition via close interplay of Z-DNA and DNA bubble.Nucleic acids research · 2021Article
- Deep learning approach for predicting functional Z-DNA regions using omics data.Scientific reports · 2020Article
- Dynamic regulation of Z-DNA in the mouse prefrontal cortex by the RNA-editing enzyme Adar1 is required for fear extinction.Nature neuroscience · 2020Article
- Article
- Z-DNA in the genome: from structure to disease.Biophysical reviews · 2019Review
- Low dose dimethyl sulfoxide driven gross molecular changes have the potential to interfere with various cellular processes.Scientific reports · 2018Article
- Human genomic Z-DNA segments probed by the Z alpha domain of ADAR1.Nucleic acids research · 2009Article
- CRH haplotype as a factor influencing cerebrospinal fluid levels of corticotropin-releasing hormone, hypothalamic-pituitary-adrenal axis activity, temperament, and alcohol consumption in rhesus macaques.Archives of general psychiatry · 2008Article
- Z-DNA-forming sequences generate large-scale deletions in mammalian cells.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Interaction of the Zalpha domain of human ADAR1 with a negatively supercoiled plasmid visualized by atomic force microscopy.Nucleic acids research · 2004Article
- Complex regulation of the human gene for the Z-DNA binding protein DLM-1.Nucleic acids research · 2002Article
- A polymorphic dinucleotide repeat in the rat nucleolin gene forms Z-DNA and inhibits promoter activity.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- The Zalpha domain from human ADAR1 binds to the Z-DNA conformer of many different sequences.Nucleic acids research · 1998Article
- Base-base and deoxyribose-base stacking interactions in B-DNA and Z-DNA: a quantum-chemical study.Biophysical journal · 1997Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The intron of the corticotropin-releasing hormone (corticoliberin; CRH) gene contains a sequence of over 100 bp of alternating purine/pyrimidine residues. We have used binding of a Z-DNA-specific antibody in metabolically active, permeabilized nuclei to study the formation of Z-DNA in this sequence at various levels of transcription. In the NPLC human primary liver carcinoma cell line, activation of cAMP-dependent pathways increased the level of transcription, while adding glucocorticoids inhibited transcription of the CRH gene. These cells respond in a manner similar to hypothalamic cells. Z-DNA formation in this sequence was detected at the basal level of transcription, as well as after stimulation with forskolin. Inhibition of transcription by dexamethasone abolished Z-DNA formation. Z-DNA formation in the WC gene (c-myc) was affected differently in the same experiment. Thus, changes in Z-DNA formation in the CRH gene are gene specific and are linked to the transcription of the gene.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.