ArticleProceedings of the National Academy of Sciences of the United States of America1996
Positive selection and rates of evolution in immunodeficiency viruses from humans and chimpanzees.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 50 citations in OpenAlex.
- A phylogenetic analysis using full-length viral genomes of South American dengue serotype 3 in consecutive Venezuelan outbreaks reveals a novel NS5 mutation.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2011Article
- Evidence for separation of HCV subtype 1a into two distinct clades.Journal of viral hepatitis · 2011Article
- Timing and evolution of the most recent common ancestor of the Korean clade HIV subtype B based on nef and vif sequences.Journal of microbiology (Seoul, Korea) · 2009Article
- Positive selection on protein-length in the evolution of a primate sperm ion channel.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Epidemiology, genetic diversity, and evolution of endemic feline immunodeficiency virus in a population of wild cougars.Journal of virology · 2003Article
- An algorithm for mapping positively selected members of quasispecies-type viruses.BMC bioinformatics · 2001Article
- Host-specific modulation of the selective constraints driving human immunodeficiency virus type 1 env gene evolution.Journal of virology · 1999Article
- Evolution and biological characterization of human immunodeficiency virus type 1 subtype E gp120 V3 sequences following horizontal and vertical virus transmission in a single family.Journal of virology · 1999Article
- A novel simian immunodeficiency virus (SIVdrl) pol sequence from the drill monkey, Mandrillus leucophaeus.Journal of virology · 1998Article
- Shortening of the symptom-free period in rhesus macaques is associated with decreasing nonsynonymous variation in the env variable regions of simian immunodeficiency virus SIVsm during passage.Journal of virology · 1998Article
- Structured-tree topology and adaptive evolution of the simian immunodeficiency virus SIVsm envelope during serial passage in rhesus macaques according to likelihood mapping and quartet puzzling.Journal of virology · 1998Article
- Likelihood models for detecting positively selected amino acid sites and applications to the HIV-1 envelope gene.Genetics · 1998Article
- Wild primate populations in emerging infectious disease research: the missing link?Emerging infectious diseasesReview
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1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evolutionary theory predicts the recent spread of primate immunodeficiency viruses (PIVs) to new human populations to be accompanied by positive selection in response to new host environments and/or by random genetic drift. I assess evidence for positive selection in human and chimpanzee PIVs type I (PIV1s), using ratios of synonymous to nonsynonymous nucleotide change based on branch lengths and outgroup rooting. Ratios are smaller for PIV1s from humans than for PIV1 from a chimpanzee for the pol, gag, and env glycoprotein 120 (gp120) regions, indicating greater effects of positive selection in PIV1s from humans. Parsimony-based relative rate tests for amino acid changes showed significant differences between PIV1s from humans and chimpanzees in 18 of 48 pairwise comparisons, with all 18 showing faster rates of change in PIV1s from humans. This study indicates that in some instances, the recent evolution of human PIV1s follows a speciational pattern, in which increased diversification of taxa is correlated with greater amounts of character change appearing and being maintained through time. This extends the generality of the speciational pattern to a group of organisms (viruses) having the fastest known rates of anagenetic change for nucleotide characters and indicates that comprehensive understanding of PIV1 evolution requires consideration of both anagenetic change within viral lineages and the relative historical success of different viral clades. Phylogenetic analyses show that neither PIV1s infecting humans nor those infecting chimpanzees represent monophyletic groups and suggest multiple host-species shifts for PIV1s.
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