ArticleProceedings of the National Academy of Sciences of the United States of America1996
DUB-1, a deubiquitinating enzyme with growth-suppressing activity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 168 citations in OpenAlex.
- Unreprogrammed H3K9me3 prevents minor zygotic genome activation and lineage commitment in SCNT embryos.Nature communications · 2023Article
- Review
- Regulatory interplay between deubiquitinating enzymes and cytokines.Cytokine & growth factor reviews · 2019Review
- Multiple functions of USP18.Cell death & disease · 2016Review
- Decision for cell fate: deubiquitinating enzymes in cell cycle checkpoint.Cellular and molecular life sciences : CMLS · 2016Review
- Article
- The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility.Nature communications · 2011Article
- Evidence for OTUD-6B participation in B lymphocytes cell cycle after cytokine stimulation.PloS one · 2011Article
- The role of deubiquitinating enzymes in apoptosis.Cellular and molecular life sciences : CMLS · 2011Review
- The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster.BMC genomics · 2010Article
- USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity.The Journal of biological chemistry · 2009Article
- Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling.Endocrine reviews · 2008Review
- USP11 stabilizes HPV-16E7 and further modulates the E7 biological activity.The Journal of biological chemistry · 2008Article
- Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability.BMC genomics · 2006Article
- SSeCKS/Gravin/AKAP12 attenuates expression of proliferative and angiogenic genes during suppression of v-Src-induced oncogenesis.BMC cancer · 2006Article
- Inhibitor of kappaB kinase is required to activate a subset of interferon gamma-stimulated genes.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Activity-based ubiquitin-specific protease (USP) profiling of virus-infected and malignant human cells.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation.The Journal of clinical investigation · 2003Article
- Gene structure, alternate splicing, tissue distribution, cellular localization, and developmental expression pattern of mouse deubiquitinating enzyme isoforms Usp2-45 and Usp2-69.Gene expression · 2003Article
- Antagonistic regulation of myogenesis by two deubiquitinating enzymes, UBP45 and UBP69.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Cytokines regulate cell growth by inducing the expression of specific target genes. Using the differential display method, we have cloned a cytokine-inducible immediate early gene, DUB-1 (for deubiquitinating enzyme). DUB-1 is related to members of the UBP superfamily of deubiquitinating enzymes, which includes the oncoprotein Tre-2. A glutathione S-transferase-DUB-1 fusion protein cleaved ubiquitin from a ubiquitin-beta-galactosidase protein. When a conserved cysteine residue of DUB-1, required for ubiquitin-specific thiol protease activity, was mutated to serine (C60S), deubiquitinating activity was abolished. Continuous expression of DUB-1 from a steroid-inducible promoter induced growth arrest in the G1 phase of the cell cycle. Cells arrested by DUB-1 expression remained viable and resumed proliferation upon steroid withdrawal. Our results suggest that DUB-1 regulates cellular growth by modulating either the ubiquitin-dependent proteolysis or the ubiquitination state of an unknown growth regulatory factor(s).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.