ArticleThe Journal of clinical investigation1996
Quantitative trait locus mapping of human blood pressure to a genetic region at or near the lipoprotein lipase gene locus on chromosome 8p22.
Article in The Journal of clinical investigation, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 123 citations in OpenAlex.
- Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci.Nature genetics · 2016Pooled it
- Variation in the lipoprotein lipase gene influences exercise-induced left ventricular growth.Journal of molecular medicine (Berlin, Germany) · 2006Trial
- Effect of the Interaction between Seaweed Intake andNutrients · 2023Article
- Article
- Genetic association study of selected candidate genes (ApoB, LPL, Leptin) and telomere length in obese and hypertensive individuals.BMC medical genetics · 2009Article
- Genetic effect on blood pressure is modulated by age: the Hypertension Genetic Epidemiology Network Study.Hypertension (Dallas, Tex. : 1979) · 2009Article
- Quantitative trait loci associated with blood pressure of metabolic syndrome in the progeny of NZO/HILtJxC3H/HeJ intercrosses.Mammalian genome : official journal of the International Mammalian Genome Society · 2007Article
- Haplotypes in the lipoprotein lipase gene influence high-density lipoprotein cholesterol response to statin therapy and progression of atherosclerosis in coronary artery bypass grafts.The pharmacogenomics journal · 2007 · on this mapArticle
- Renal tubular transport and the genetic basis of hypertensive disease.Clinical and experimental nephrology · 2005Review
- Genetic variations related to hypertension: a review.Journal of human hypertension · 2005Review
- Lipoprotein lipase and its role in regulation of plasma lipoproteins and cardiac risk.Current atherosclerosis reports · 2004Review
- Lipoprotein lipase gene is in linkage with blood pressure phenotypes in Chinese pedigrees.Human genetics · 2004Article
- Linkage analysis of five candidate genes and essential hypertension in 106 Chinese nuclear families.Journal of human hypertension · 2003Article
- Pharmacogenetic approaches to hypertension therapy: design and rationale for the Genetics of Hypertension Associated Treatment (GenHAT) study.The pharmacogenomics journal · 2002Article
- Review
- Autosomal dominant orthostatic hypotensive disorder maps to chromosome 18q.American journal of human genetics · 1998Article
- Complex genetic contribution of the Apo AI-CIII-AIV gene cluster to familial combined hyperlipidemia. Identification of different susceptibility haplotypes.The Journal of clinical investigation · 1997Article
- Evidence for linkage of a candidate chromosome 1 region to human systemic lupus erythematosus.The Journal of clinical investigation · 1997Article
- Complex trait genetics: new methods yield a result for essential hypertension.The Journal of clinical investigation · 1996Article
- Linkage mapping for hypertension susceptibility genes.Current hypertension reportsReview
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
Abstract
Resistance to insulin-mediated glucose disposal is a common finding in patients with non-insulin-dependent diabetes mellitus (NIDDM), as well as in nondiabetic individuals with hypertension. In an effort to identify the generic loci responsible for variations in blood pressure in individuals at increased risk of insulin resistance, we studied the distribution of blood pressure in 48 Taiwanese families with NIDDM and conducted quantitative sib-pair linkage analysis with candidate loci for insulin resistance, lipid metabolism, and blood pressure control. We found no evidence for linkage of the angiotensin converting enzyme locus on chromosome 17, nor the angiotensinogen and renin loci on chromosome 1, with either systolic or diastolic blood pressures. In contrast, we obtained significant evidence for linkage or systolic blood pressure, but not diastolic blood pressure, to a genetic region at or near the lipoprotein lipase (LPL) locus on the short arm of chromosome 8 (P = 0.002, n = 125 sib-pairs, for the haplotype generated from two simple sequence repeat markers within the LPL gene). Further strengthening this linkage observation, two flanking marker loci for LPL locus, D8S261 (9 cM telomeric to LPL locus) and D8S282 (3 cM centromeric to LPL locus), also showed evidence for linkage with systolic blood pressure (P = 0.02 and 0.0002 for D8S261 and D8S282, respectively). Two additional centromeric markers (D8S133, 5 cM from LPL locus, and NEFL, 11 cM from LPL locus) yielded significant P values of 0.01 and 0.001, respectively. Allelic variation around the LPL gene locus accounted for as much as 52-73% of the total interindividual variation in systolic blood pressure levels in this data set. Thus, we have identified a genetic locus at or near the LPL gene locus which contributes to the variation of systolic blood pressure levels in nondiabetic family members at high risk for insulin resistance and NIDDM.
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