ArticleThe Journal of clinical investigation1996
Nitric oxide inhibits viral replication in murine myocarditis.
Article in The Journal of clinical investigation, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 251 citations in OpenAlex.
- Arginine depletion-induced autophagy and metabolic dysregulation are involved in the disease severity of hand, foot, and mouth disease.Virulence · 2025Article
- Heart-specific NFAT5 knockout suppresses type I interferon signaling and aggravates coxsackievirus-induced myocarditis.Basic research in cardiology · 2024Article
- Metabolic profiling, antimicrobial, anticancer, and in vitro and in silico immunomodulatory investigation of Aspergillus niger OR730979 isolated from the Western Desert, Egypt.International microbiology : the official journal of the Spanish Society for Microbiology · 2024Article
- Myco-Synthesized Selenium Nanoparticles as Wound Healing and Antibacterial Agent: An In Vitro and In Vivo Investigation.Microorganisms · 2023Article
- Inhibitory effects ofHeliyon · 2023Article
- Critical role of nitric oxide in impeding COVID-19 transmission and prevention: a promising possibility.Environmental science and pollution research international · 2022Review
- Targeting Arginine in COVID-19-Induced Immunopathology and Vasculopathy.Metabolites · 2022Review
- Antiviral Activity of Nitrosonium Cations against SARS-CoV-2 on a Syrian Hamster Model.Biophysics · 2022Article
- The role of NO in COVID-19 and potential therapeutic strategies.Free radical biology & medicine · 2021Review
- Inhibition of Type III Interferon Expression in Intestinal Epithelial Cells-A Strategy Used by Coxsackie B Virus to Evade the Host's Innate Immune Response at the Primary Site of Infection?Microorganisms · 2021Article
- Gaseous Nitric Oxide and Dinitrosyl Iron Complexes with Thiol-Containing Ligands as Potential Medicines that Can Relieve COVID-19.Biophysics · 2021Article
- The Macrophage in Cardiac Homeostasis and Disease: JACC Macrophage in CVD Series (Part 4).Journal of the American College of Cardiology · 2018Review
- Blast exposure elicits blood-brain barrier disruption and repair mediated by tight junction integrity and nitric oxide dependent processes.Scientific reports · 2018Article
- Cleavage of osmosensitive transcriptional factor NFAT5 by Coxsackieviral protease 2A promotes viral replication.PLoS pathogens · 2017Article
- Rosmarinic Acid Methyl Ester Inhibits LPS-Induced NO Production via Suppression of MyD88- Dependent and -Independent Pathways and Induction of HO-1 in RAW 264.7 Cells.Molecules (Basel, Switzerland) · 2016Article
- Activation of toll-like receptor signaling pathways leading to nitric oxide-mediated antiviral responses.Archives of virology · 2016Review
- Type III interferons are expressed by Coxsackievirus-infected human primary hepatocytes and regulate hepatocyte permissiveness to infection.Clinical and experimental immunology · 2014Article
- Targeting matrix metalloproteinase activity and expression for the treatment of viral myocarditis.Journal of cardiovascular translational research · 2014Review
- The role of myeloid cell activation and arginine metabolism in the pathogenesis of virus-induced diseases.Frontiers in immunology · 2014Review
- Immunomodulatory effects of mesenchymal stromal cells revisited in the context of inflammatory cardiomyopathy.Stem cells international · 2013Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Nitric oxide (NO) is a radical molecule that not only serves as a vasodilator and neurotransmitter but also acts as a cytotoxic effector molecule of the immune system. The inducible enzyme making NO, inducible NO synthase (iNOS), is transcriptionally activated by IFN-gamma and TNF-alpha, cytokines which are produced during viral infection. We show that iNOS is induced in mice infected with the Coxsackie B3 virus. Macrophages expressing iNOS are identified in the hearts and spleens of infected animals with an antibody raised against iNOS. Infected mice have increased titers of virus and a higher mortality when fed NOS inhibitors. Thus, viral infection induces iNOS in vivo, and NO inhibits viral replication. NO is a novel, nonspecific immune defense against viruses in vivo.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.