ArticleProceedings of the National Academy of Sciences of the United States of America1995
Orp1, a member of the Cdc18/Cdc6 family of S-phase regulators, is homologous to a component of the origin recognition complex.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 98 citations in OpenAlex.
- Origin recognition complex subunit 1(ORC1) is a potential biomarker and therapeutic target in cancer.BMC medical genomics · 2023Article
- Mechanisms and regulation of DNA replication initiation in eukaryotes.Critical reviews in biochemistry and molecular biology · 2017Review
- Schizosaccharomyces pombe minichromosome maintenance-binding protein (MCM-BP) antagonizes MCM helicase.The Journal of biological chemistry · 2011Article
- Trypanosome prereplication machinery contains a single functional orc1/cdc6 protein, which is typical of archaea.Eukaryotic cell · 2009Article
- Cdc6 ATPase activity regulates ORC x Cdc6 stability and the selection of specific DNA sequences as origins of DNA replication.The Journal of biological chemistry · 2007Article
- Identification of cell cycle-regulated genes in fission yeast.Molecular biology of the cell · 2005Article
- An archaeal chromosomal autonomously replicating sequence element from an extreme halophile, Halobacterium sp. strain NRC-1.Journal of bacteriology · 2003Article
- Functional genomic analysis reveals distinct neoplastic phenotypes associated with c-myb mutation in the bursa of Fabricius.Oncogene · 2003Article
- DNA replication and damage checkpoints and meiotic cell cycle controls in the fission and budding yeasts.The Biochemical journal · 2000Review
- Article
- Association of fission yeast Orp1 and Mcm6 proteins with chromosomal replication origins.Molecular and cellular biology · 1999Article
- Clustered adenine/thymine stretches are essential for function of a fission yeast replication origin.Molecular and cellular biology · 1999Article
- A fission yeast gene, him1(+)/dfp1(+), encoding a regulatory subunit for Hsk1 kinase, plays essential roles in S-phase initiation as well as in S-phase checkpoint control and recovery from DNA damage.Molecular and cellular biology · 1999Article
- Cell cycle regulation of Dfp1, an activator of the Hsk1 protein kinase.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Assembly of functionally active Drosophila origin recognition complex from recombinant proteins.Genes & development · 1999Article
- E2F mediates developmental and cell cycle regulation of ORC1 in Drosophila.The EMBO journal · 1999Article
- The role of nucleotide binding and hydrolysis in the function of the fission yeast cdc18(+) gene product.Genetics · 1999Article
- The fission yeast homologue of Orc4p binds to replication origin DNA via multiple AT-hooks.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Fission yeast cdc24 is a replication factor C- and proliferating cell nuclear antigen-interacting factor essential for S-phase completion.Molecular and cellular biology · 1999Article
- Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization.The EMBO journal · 1999Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
cdc18+ of Schizosaccharomyces pombe is a periodically expressed gene that is required for entry into S phase and for the coordination of S phase with mitosis. cdc18+ is related to the Saccharomyces cerevisiae gene CDC6, which has also been implicated in the control of DNA replication. We have identified a new Sch. pombe gene, orp1+, that encodes an 80-kDa protein with amino acid sequence motifs conserved in the Cdc18 and Cdc6 proteins. Genetic analysis indicates that orp1+ is essential for viability. Germinating spores lacking the orp1+ gene are capable of undergoing one or more rounds of DNA replication but fail to progress further, arresting as long cells with a variety of deranged nuclear structures. Unlike cdc18+, orp1+ is expressed constitutively during the cell cycle. cdc18+, CDC6, and orp1+ belong to a family of related genes that also includes the gene ORC1, which encodes a subunit of the origin recognition complex (ORC) of S. cerevisiae. The products of this gene family share a 250-amino acid domain that is highly conserved in evolution and contains several characteristic motifs, including a consensus purine nucleotide-binding motif. Among the members of this gene family, orp1+ is most closely related to S. cerevisiae ORC1. Thus, the protein encoded by orp1+ may represent a component of an Sch. pombe ORC. The orp1+ gene is also closely related to an uncharacterized putative human homologue. It is likely that the members of the cdc18/CDC6 family play key roles in the regulation of DNA replication during the cell cycle of diverse species from archaebacteria to man.
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