ArticleProceedings of the National Academy of Sciences of the United States of America1995
Pulmonary malformation in transgenic mice expressing human keratinocyte growth factor in the lung.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 183 citations in OpenAlex.
- Congenital pulmonary airway malformation type 2 associated with intralobar pulmonary sequestration in an adult patient: a case report.Future science OA · 2025Article
- Congenital lung malformations.Nature reviews. Disease primers · 2023Review
- RTK signalling promotes epithelial columnar cell shape and apical junction maintenance in human lung progenitor cells.Development (Cambridge, England) · 2023Article
- Mechanics of Lung Development.Advances in anatomy, embryology, and cell biology · 2023Article
- Defining the spatial landscape of KRAS mutated congenital pulmonary airway malformations: a distinct entity with a spectrum of histopathologic features.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2022Article
- Review
- Epithelial cell-adhesion protein cadherin 26 is dysregulated in congenital diaphragmatic hernia and congenital pulmonary airway malformation.Pediatric surgery international · 2021Article
- Organ-Specific Branching Morphogenesis.Frontiers in cell and developmental biology · 2021Review
- FGF/FGFR signaling in health and disease.Signal transduction and targeted therapy · 2020Review
- Fgf10 Signaling in Lung Development, Homeostasis, Disease, and Repair After Injury.Frontiers in genetics · 2018Review
- Genomic analysis identified a potential novel molecular mechanism for high-altitude adaptation in sheep at the Himalayas.Scientific reports · 2016Article
- Efficacy of a Cancer Vaccine against ALK-Rearranged Lung Tumors.Cancer immunology research · 2015Article
- Palifermin for the protection and regeneration of epithelial tissues following injury: new findings in basic research and pre-clinical models.Journal of cellular and molecular medicine · 2013Review
- Congenital lung lesions: prenatal MRI and postnatal findings.Pediatric radiology · 2013Article
- Hepatocyte growth factor, a determinant of airspace homeostasis in the murine lung.PLoS genetics · 2013Article
- KGF-2 targets alveolar epithelia and capillary endothelia to reduce high altitude pulmonary oedema in rats.Journal of cellular and molecular medicine · 2012Article
- Association between fibroblast growth factor 7 and the risk of chronic obstructive pulmonary disease.Acta pharmacologica Sinica · 2012Article
- Exogenous fibroblast growth factor-10 induces cystic lung development with altered target gene expression in the presence of heparin in cultures of embryonic rat lung.Pathobiology : journal of immunopathology, molecular and cellular biology · 2012Article
- Article
- Epithelial repair mechanisms in the lung.American journal of physiology. Lung cellular and molecular physiology · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Expression of human keratinocyte growth factor (KGF/FGF-7) was directed to epithelial cells of the developing embryonic lung of transgenic mice disrupting normal pulmonary morphogenesis during the pseudoglandular stage of development. By embryonic day 15.5(E15.5), lungs of transgenic surfactant protein C (SP-C)-KGF mice resembled those of humans with pulmonary cystadenoma. Lungs were cystic, filling the thoracic cavity, and were composed of numerous dilated saccules lined with glycogen-containing columnar epithelial cells. The normal distribution of SP-C proprotein in the distal regions of respiratory tubules was disrupted. Columnar epithelial cells lining the papillary structures stained variably and weakly for this distal respiratory cell marker. Mesenchymal components were preserved in the transgenic mouse lungs, yet the architectural relationship of the epithelium to the mesenchyme was altered. SP-C-KGF transgenic mice failed to survive gestation to term, dying before E17.5. Culturing mouse fetal lung explants in the presence of recombinant human KGF also disrupted branching morphogenesis and resulted in similar cystic malformation of the lung. Thus, it appears that precise temporal and spatial expression of KGF is likely to play a crucial role in the control of branching morphogenesis during fetal lung development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.