ArticleProceedings of the National Academy of Sciences of the United States of America1995
Ceramide formation during heat shock: a potential mediator of alpha B-crystallin transcription.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed, 100 citations in OpenAlex.
- Association between ambient temperature and thrombosis-related signaling lipids: Implications for early cardiovascular risk.Journal of exposure science & environmental epidemiology · 2026Article
- Structural Control for Tunable Hyperthermia-Induced Cellular Responses Using 3D-Printed Platforms.ACS biomaterials science & engineering · 2025Article
- Lipid Composition Analysis and Characterization of Acyl Sterol Glycosides in Adzuki and Soybean Cultivars by Non-Targeted LC-MS.Foods (Basel, Switzerland) · 2023Article
- Article
- The ERAD system is restricted by elevated ceramides.Science advances · 2023Article
- A theoretical model of dietary lipid variance as the origin of primary ciliary dysfunction in preeclampsia.Frontiers in molecular biosciences · 2023Article
- Alkaline ceramidase (Frontiers in physiology · 2023Article
- Sphingomyelinases in retinas and optic nerve heads: Effects of ocular hypertension and ischemia.Experimental eye research · 2022Article
- Lipid profiling of mouse intestinal organoids for studying APC mutations.Bioscience reports · 2021Article
- The dynamics and role of sphingolipids in eukaryotic organisms upon thermal adaptation.Progress in lipid research · 2020Review
- FTY720 (Fingolimod) Ameliorates Brain Injury through Multiple Mechanisms and is a Strong Candidate for Stroke Treatment.Current medicinal chemistry · 2020Review
- A neutral ceramidase, NlnCDase, is involved in the stress responses of brown planthopper, Nilaparvata lugens (Stål).Scientific reports · 2018Article
- Translational Aspects of Sphingolipid Metabolism in Renal Disorders.International journal of molecular sciences · 2017Review
- Stress-induced ceramide generation and apoptosis via the phosphorylation and activation of nSMase1 by JNK signaling.Cell death and differentiation · 2015Article
- Sphingolipids in cardiovascular and cerebrovascular systems: Pathological implications and potential therapeutic targets.World journal of cardiology · 2013Article
- Identification of Mg2+ -dependent neutral sphingomyelinase 1 as a mediator of heat stress-induced ceramide generation and apoptosis.The Journal of biological chemistry · 2008Article
- Distinct roles for de novo versus hydrolytic pathways of sphingolipid biosynthesis in Saccharomyces cerevisiae.The Biochemical journal · 2006Article
- Activation of the mitogen-activated protein kinase pathways by heat shock.Cell stress & chaperones · 2002Review
- Characterization of zebrafish caspase-3 and induction of apoptosis through ceramide generation in fish fathead minnow tailbud cells and zebrafish embryo.The Biochemical journal · 2001Article
- tau kinases in the rat heat shock model: possible implications for Alzheimer disease.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Ceramide has been identified as a potential second messenger that may mediate cell differentiation and apoptosis after exposure to hormonal agonists such as 1 alpha, 25-dihydroxyvitamin D3, tumor necrosis factor alpha, or gamma-interferon. The secondary cellular events that follow ceramide generation remain undefined. We report that in NIH WT-3T3 cells, ceramide induces an enhancement of gene transcription of alpha B-crystallin, a small heat shock protein. The levels of alpha B-crystallin, as measured by Northern blot and immunoblot analyses, were increased by the addition of an exogenous short-chain ceramide, N-acetylsphingosine, or by increasing endogenous intracellular ceramide by inhibition of glucosylceramide synthase. Similar effects were not seen in the expression of the closely related gene, Hsp25. To ascertain whether ceramide-mediated gene transcription was a feature of the heat shock response, cell ceramide was measured in heat shocked cells and observed to be elevated 2-fold immediately upon the return of cells to 37 degrees C. Thus ceramide formed after heat shock treatment of 3T3 cells may mediate the transcription events associated with the cell stress response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.