ArticleThe EMBO journal1996
A new Drosophila Ca2+/calmodulin-dependent protein kinase (Caki) is localized in the central nervous system and implicated in walking speed.
Article in The EMBO journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 65 citations in OpenAlex.
- Drosophila CASK regulates brain size and neuronal morphogenesis, providing a genetic model of postnatal microcephaly suitable for drug discovery.Neural development · 2023Article
- Hsrω and Other lncRNAs in Neuronal Functions and Disorders inLife (Basel, Switzerland) · 2022Review
- The Non-Linear Path from Gene Dysfunction to Genetic Disease: Lessons from the MICPCH Mouse Model.Cells · 2022Review
- Extensive Differential Splicing Underlies Phenotypically Plastic Aphid Morphs.Molecular biology and evolution · 2018Article
- Mechanisms of Long Non-Coding RNAs in the Assembly and Plasticity of Neural Circuitry.Frontiers in neural circuits · 2017Review
- Development of the Cellular Immune System of Drosophila Requires the Membrane Attack Complex/Perforin-Like Protein Torso-Like.Genetics · 2016Article
- Neural functions of long noncoding RNAs in Drosophila.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2015Review
- Regulation of dopamine release by CASK-β modulates locomotor initiation in Drosophila melanogaster.Frontiers in behavioral neuroscience · 2014Article
- CASK and CaMKII function in Drosophila memory.Frontiers in neuroscience · 2014Review
- Neuron-specific protein interactions of Drosophila CASK-β are revealed by mass spectrometry.Frontiers in molecular neuroscience · 2014Article
- CASK and CaMKII function in the mushroom body α'/β' neurons during Drosophila memory formation.Frontiers in neural circuits · 2013Article
- The novel long non-coding RNA CRG regulates Drosophila locomotor behavior.Nucleic acids research · 2012Article
- Conserved and divergent elements in Torso RTK activation in Drosophila development.Scientific reports · 2012Article
- Identification, expression and target gene analyses of Micrornas in Spodoptera litura.PloS one · 2012Article
- Central regulation of locomotor behavior of Drosophila melanogaster depends on a CASK isoform containing CaMK-like and L27 domains.Genetics · 2011Article
- Neurexin in embryonic Drosophila neuromuscular junctions.PloS one · 2010Article
- High-resolution video tracking of locomotion in adult Drosophila melanogaster.Journal of visualized experiments : JoVE · 2009Article
- Article
- DLGS97/SAP97 is developmentally upregulated and is required for complex adult behaviors and synapse morphology and function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Deletion of CASK in mice is lethal and impairs synaptic function.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Calcium/calmodulin-dependent protein kinases (CaM kinases) have been reported to be involved in neuroplasticity. We have cloned a new Drosophila CaM kinase gene named caki. We describe the molecular characterization of caki and a behavioral effect of its elimination. The caki gene is extremely large; comparison of the genomic and cDNA sequences reveals that the caki transcription unit is at least 150 kb. The catalytic domain of this new CaM kinase protein shares homology (41%) with type II CaM kinases, while the C-terminal part is divergent. Constitutively expressed Caki protein is enzymatically active since it causes a 3-fold increase in the level of the Rous sarcoma virus long terminal repeat (RSV LTR) promoter in a co-transfusion assay. In situ hybridization shows that during embryogenesis, larval and pupal life, transcription of caki is restricted almost exclusively to the central nervous system. In the adult head, immunohistochemistry reveals Caki protein in the lamina, the neuropil of the medulla, lobula, lobula plate and in the central brain. Mutant caki flies show reduced walking speed in 'Buridan's paradigm'.
Indexed as
Identifiers
8617233PMC450104W121356167What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.