ArticleThe EMBO journal1996
GATA transcription factors associate with a novel class of nuclear bodies in erythroblasts and megakaryocytes.
Article in The EMBO journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 64 citations in OpenAlex.
- Compound heterozygous GATA5 mutations in a girl with hydrops fetalis, congenital heart defects and genital anomalies.Human genetics · 2017Article
- GATA1 Activity Governed by Configurations ofFrontiers in oncology · 2016Review
- Article
- Analysis of the cellular localization of herpes simplex virus 1 immediate-early protein ICP22.Virologica Sinica · 2010Article
- Controlling hematopoiesis through sumoylation-dependent regulation of a GATA factor.Molecular cell · 2009Article
- ErythRED, a hESC line enabling identification of erythroid cells.Nature methods · 2009Article
- Transcription factories: gene expression in unions?Nature reviews. Genetics · 2009Review
- Non-random subcellular distribution of variant EKLF in erythroid cells.Experimental cell research · 2008Article
- A generic tool for biotinylation of tagged proteins in transgenic mice.Transgenic research · 2005Article
- GATA-1 forms distinct activating and repressive complexes in erythroid cells.The EMBO journal · 2005Article
- Modification of the erythroid transcription factor GATA-1 by SUMO-1.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Efficient biotinylation and single-step purification of tagged transcription factors in mammalian cells and transgenic mice.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Transforming growth factor beta blocks Tec kinase phosphorylation, Ca2+ influx, and NFATc translocation causing inhibition of T cell differentiation.The Journal of experimental medicine · 2003Article
- Green fluorescent protein-Dal80p illuminates up to 16 distinct foci that colocalize with and exhibit the same behavior as chromosomal DNA proceeding through the cell cycle of Saccharomyces cerevisiae.Journal of bacteriology · 2001Article
- Potentiation of GATA-2 activity through interactions with the promyelocytic leukemia protein (PML) and the t(15;17)-generated PML-retinoic acid receptor alpha oncoprotein.Molecular and cellular biology · 2000Article
- An intrinsic but cell-nonautonomous defect in GATA-1-overexpressing mouse erythroid cells.Nature · 2000Article
- Spatial organization of RNA polymerase II transcription in the nucleus.Nucleic acids research · 2000Review
- Direct visualization of the elt-2 gut-specific GATA factor binding to a target promoter inside the living Caenorhabditis elegans embryo.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- The solution structure of the N-terminal zinc finger of GATA-1 reveals a specific binding face for the transcriptional co-factor FOG.Journal of biomolecular NMR · 1999Article
- Regional and temporal specialization in the nucleus: a transcriptionally-active nuclear domain rich in PTF, Oct1 and PIKA antigens associates with specific chromosomes early in the cell cycle.The EMBO journal · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nuclear distribution of GATA transcription factors in murine haemopoietic cells was examined by indirect immunofluorescence. Specific bright foci of GATA-1 fluorescence were observed in erythroleukaemia cells and primary murine erythroblasts and megakaryocytes, in addition to diffuse nucleoplasmic localization. These foci, which were preferentially found adjacent to nucleoli or at the nuclear periphery, did not represent sites of active transcription or binding of GATA-1 to consensus sites in the beta-globin loci. Immunoelectron microscopy demonstrated the presence of intensely labelled structures likely to represent the GATA-1 foci seen by immunofluorescence. The GATA-1 nuclear bodies differed from previously described nuclear structures and there was no co-localization with nuclear antigens involved in RNA processing or other ubiquitous (Spl, c-Jun and TBP) or haemopoietic (NF-E2) transcription factors. Interestingly, GATA-2 and GATA-3 proteins also localized to the same nuclear bodies in cell lines co-expressing GATA-1 and -2 or GATA-1 and -3 gene products. This pattern of distribution is, thus far, unique to the GATA transcription factors and suggests a protein-protein interaction with other components of the nuclear bodies via the GATA zinc finger domain.
Indexed as
Identifiers
8617207PMC449947W1533848369What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.