ArticleThe Journal of clinical investigation1996
In vivo neutralization of eosinophil-derived major basic protein inhibits antigen-induced bronchial hyperreactivity in sensitized guinea pigs.
Article in The Journal of clinical investigation, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 83 citations in OpenAlex.
- Lung Pathologies in a Chronic Inflammation Mouse Model Are Independent of Eosinophil Degranulation.American journal of respiratory and critical care medicine · 2017Article
- Novel Therapies for Eosinophilic Disorders.Immunology and allergy clinics of North America · 2015Review
- Effect of antigen sensitization and challenge on oscillatory mechanics of the lung and pulmonary inflammation in obese carboxypeptidase E-deficient mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- The p110δ subunit of PI3K regulates bone marrow-derived eosinophil trafficking and airway eosinophilia in allergen-challenged mice.American journal of physiology. Lung cellular and molecular physiology · 2012Article
- Anti-inflammatory, immunomodulatory, and heme oxygenase-1 inhibitory activities of ravan napas, a formulation of uighur traditional medicine, in a rat model of allergic asthma.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- What targeting eosinophils has taught us about their role in diseases.The Journal of allergy and clinical immunology · 2010Review
- Distribution of major basic protein on human airway following in vitro eosinophil incubation.Mediators of inflammation · 2010Article
- Ibuprofen and increased morbidity in children with asthma: fact or fiction?Paediatric drugs · 2004Review
- Blockade of inflammation and airway hyperresponsiveness in immune-sensitized mice by dominant-negative phosphoinositide 3-kinase-TAT.The Journal of experimental medicine · 2003Article
- [Allergy-associated colitis. Characterization of an entity and its differential diagnoses].Der Pathologe · 2003Review
- Animal models of allergic asthma.Current allergy and asthma reports · 2003Review
- Mammalian antibiotic peptides.Folia microbiologica · 2003Review
- A comparison of allergen and polycation induced cutaneous responses in the rabbit.British journal of pharmacology · 2001Article
- Prevention of antigen-induced bronchial hyperreactivity and airway inflammation in sensitized guinea-pigs by tacrolimus.Mediators of inflammation · 1999Article
- Interleukin-12 suppresses filaria-induced pulmonary eosinophilia, deposition of major basic protein and airway hyperresponsiveness.Parasite immunology · 1998Article
- An essential role for interleukin-5 and eosinophils in helminth-induced airway hyperresponsiveness.Infection and immunity · 1998Article
- Pulmonary neuronal M2 muscarinic receptor function in asthma and animal models of hyperreactivity.Thorax · 1998Review
- Review
- Pretreatment with antibody to eosinophil major basic protein prevents hyperresponsiveness by protecting neuronal M2 muscarinic receptors in antigen-challenged guinea pigs.The Journal of clinical investigation · 1997Article
- Kinetics of eotaxin generation and its relationship to eosinophil accumulation in allergic airways disease: analysis in a guinea pig model in vivo.The Journal of experimental medicine · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study examines the effect of purified rabbit antiguinea pig eosinophil-derived major basic protein (MBP) Ig on antigen-induced bronchial hyperreactivity to inhaled acetylcholine in aerosol-sensitized guinea pigs. Ovalbumin inhalation by sensitized guinea pigs induced a rise in the numbers of eosinophils and in the levels of MBP in the bronchoalveolar lavage fluid, which peaked at 24 h and resolved at 72 h. Antigen-challenged animals exhibited bronchial hyperreactivity to inhale acetylcholine at 72 h, but not at 6 or 24 h. The intranasal administration of 200 microliter of purified rabbit anti-guinea pig MBP Ig, at 2.5 mg/ml, but not of the control preimmune rabbit Ig, 1 h before and 5 h after ovalbumin inhalation suppressed bronchial hyperreactivity to acetylcholine at 72 h without affecting the number of eosinophils accumulating in the bronchoalveolar lavage fluid. These findings indicate that antigen challenge in sensitized guinea pigs is followed by early eosinophil infiltration and activation within the airways and by late bronchial hyperreactivity. Neutralization of endogenously secreted MBP by a specific antiserum prevented antigen-induced bronchial hyperreactivity, suggesting that eosinophil degranulation plays an important role in the alterations of bronchopulmonary function in the guinea pig.
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