ArticleInfection and immunity1996
Upregulation of tumor necrosis factor alpha and interleukin-1 beta in Q fever endocarditis.
Article in Infection and immunity, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 57 citations in OpenAlex.
- Genome characteristics and type IV effector protein repertoire of Coxiella burnetii depend rather on Genomic Groups than on host species.BMC microbiology · 2026Article
- QuilA® adjuvanted Coxevac® sustains Th1-CD8NPJ vaccines · 2023Article
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- Expression of human TLR4/myeloid differentiation factor 2 directs an early innate immune response associated with modest increases in bacterial burden duringInnate immunity · 2019Article
- Host and Bacterial Factors Control Susceptibility of Drosophila melanogaster to Coxiella burnetii Infection.Infection and immunity · 2017Article
- From Q Fever to Coxiella burnetii Infection: a Paradigm Change.Clinical microbiology reviews · 2017Review
- Type I Interferon Counters or Promotes Coxiella burnetii Replication Dependent on Tissue.Infection and immunity · 2016Article
- Cytokine Signature in Infective Endocarditis.PloS one · 2015Article
- The effect of C. burnetii infection on the cytokine response of PBMCs from pregnant goats.PloS one · 2014Article
- Coxiella burnetii induces apoptosis during early stage infection via a caspase-independent pathway in human monocytic THP-1 cells.PloS one · 2012Article
- Role for the CD28 molecule in the control of Coxiella burnetii infection.Infection and immunity · 2006Article
- Evaluation of sedimentation rate, rheumatoid factor, C-reactive protein, and tumor necrosis factor for the diagnosis of infective endocarditis.Clinical and vaccine immunology : CVI · 2006Article
- SCID mouse model for lethal Q fever.Infection and immunity · 2003Article
- Interleukin-10 stimulates Coxiella burnetii replication in human monocytes through tumor necrosis factor down-modulation: role in microbicidal defect of Q fever.Infection and immunity · 2001Article
- alpha(v)beta(3) integrin and bacterial lipopolysaccharide are involved in Coxiella burnetii-stimulated production of tumor necrosis factor by human monocytes.Infection and immunity · 2000Article
- The 75-kD tumour necrosis factor (TNF) receptor is specifically up-regulated in monocytes during Q fever endocarditis.Clinical and experimental immunology · 2000Article
- Reduced transendothelial migration of monocytes infected by Coxiella burnetii.Infection and immunity · 2000Article
- Coxiella burnetii survives in monocytes from patients with Q fever endocarditis: involvement of tumor necrosis factor.Infection and immunity · 2000Article
- Q fever.Clinical microbiology reviews · 1999Review
- Circulating cytokine balance and activation markers of leucocytes in Q fever.Clinical and experimental immunology · 1999Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The occurrence of Q fever endocarditis likely involves some alterations in the responses of monocytes, the in vivo targets of Coxiella burnetii. To test this hypothesis, the production of the inflammatory cytokines tumor necrosis factor alpha, interleukin-1 beta, and interleukin-6 was assessed in monocytes from patients with Q fever endocarditis. Spontaneous transcription and secretion of tumor necrosis factor and interleukin-1 were significantly higher in patient monocytes than in healthy controls. The interleukin-6 transcripts were also upregulated in patient cells. Moreover, in patients with recent endocarditis exhibiting high titers of immunoglobulin G directed to C. burnetii in phase I, monocytes released significantly higher levels of tumor necrosis factor and interleukin-1 than in patients with stabilized endocarditis. Immunoglobulin G titers and the overproduction of tumor necrosis factor and interleukin-1 were significantly correlated. Hence, the overproduction of inflammatory cytokines might be a marker of disease activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.