ArticleThe EMBO journal1996
A novel circadianly expressed Drosophila melanogaster gene dependent on the period gene for its rhythmic expression.
Article in The EMBO journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 57 citations in OpenAlex.
- Article
- Brain Gene Expression of Foraging Behavior and Social Environment in Ceratina calcarata.Genome biology and evolution · 2023Article
- Molecular Diagnostics for Ocular Infectious Diseases: LXXVIII Edward Jackson Memorial Lecture.American journal of ophthalmology · 2022Review
- Mathematical model of the Drosophila circadian clock: loop regulation and transcriptional integration.Biophysical journal · 2009Article
- A functional genomics strategy reveals clockwork orange as a transcriptional regulator in the Drosophila circadian clock.Genes & development · 2007Article
- Influence of the period-dependent circadian clock on diurnal, circadian, and aperiodic gene expression in Drosophila melanogaster.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Article
- takeout, a novel Drosophila gene under circadian clock transcriptional regulation.Molecular and cellular biology · 2000Article
- Ectopic expression of the neuropeptide pigment-dispersing factor alters behavioral rhythms in Drosophila melanogaster.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Differential regulation of circadian pacemaker output by separate clock genes in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Circadian regulation of a Drosophila homolog of the mammalian Clock gene: PER and TIM function as positive regulators.Molecular and cellular biology · 1998Article
- Drosophila photoreceptors contain an autonomous circadian oscillator that can function without period mRNA cycling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Spatial and temporal expression of the period and timeless genes in the developing nervous system of Drosophila: newly identified pacemaker candidates and novel features of clock gene product cycling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Multiple circadian-regulated elements contribute to cycling period gene expression in Drosophila.The EMBO journal · 1997Article
- AtGRP7, a nuclear RNA-binding protein as a component of a circadian-regulated negative feedback loop in Arabidopsis thaliana.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- A circadian enhancer mediates PER-dependent mRNA cycling in Drosophila melanogaster.Molecular and cellular biology · 1997Article
- A new gene encoding a putative transcription factor regulated by the Drosophila circadian clock.The EMBO journal · 1997Article
- Downloading central clock information in Drosophila.Molecular neurobiologyReview
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Drosophila melanogaster period (per) gene is required for expression of endogenous circadian rhythms of locomotion and eclosion. per mRNA is expressed with a circadian rhythm that is dependent on Per protein; this feedback loop has been proposed to be essential to the central circadian pacemaker. This model would suggest the Per protein also controls the circadian expression of other genetic loci to generate circadian behavior and physiology. In this paper we describe Dreg-5, a gene whose mRNA is expressed in fly heads with a circadian rhythm nearly identical to that of the per gene. Dreg-5 mRNA continues to cycle in phase with that of per mRNA in conditions of total darkness and also when the daily feeding time is altered. Like per mRNA, Dreg-5 mRNA is not expressed rhythmically in per null mutant flies. Dreg-5 encodes a novel 298 residue protein and Dreg-5 protein isoforms also oscillate in abundance with a circadian rhythm. The phase of Dreg-5 protein oscillation, however, is different from that of Per protein expression, suggesting that Dreg-5 and per have common translational but different post-translational control mechanisms. These results demonstrate that the per gene is capable of modulating the rhythmic expression of other genes; this activity may form the basis of the output of circadian rhythmicity in Drosophila.
Indexed as
Identifiers
8612586PMC450072W69121343What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.