ArticleThe EMBO journal1996
Differentiation and growth arrest signals are generated through the cytoplasmic region of gp130 that is essential for Stat3 activation.
Article in The EMBO journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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Who cites it
63 citing papers in PubMed.
- Receptor engineering constitutes feedback control and robustness of IL-23R signaling and highlights importance of intracellular cytokine receptor signaling motifs.Cell communication and signaling : CCS · 2026Article
- TRP75-mediated STAT3 activation promotes anti-apoptotic signaling andInfection and immunity · 2025Article
- Cold Storage Followed by Transplantation Induces Interferon-Gamma and STAT-1 in Kidney Grafts.International journal of molecular sciences · 2023Article
- miR-181a/b downregulation: a mutation-independent therapeutic approach for inherited retinal diseases.EMBO molecular medicine · 2022Article
- IL-6 in inflammation, autoimmunity and cancer.International immunology · 2021Review
- STAT3 plays an important role in DNA replication by turning on WDHD1.Cell & bioscience · 2021Article
- Essential Role of STAT3 Signaling in Hair Follicle Homeostasis.Frontiers in immunology · 2021Article
- Article
- Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome.The Journal of experimental medicine · 2020Article
- Synthetic cytokine receptors transmit biological signals using artificial ligands.Nature communications · 2018Article
- Smad7 enables STAT3 activation and promotes pluripotency independent of TGF-β signaling.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Model Based Targeting of IL-6-Induced Inflammatory Responses in Cultured Primary Hepatocytes to Improve Application of the JAK Inhibitor Ruxolitinib.Frontiers in physiology · 2017Article
- Interleukin-6 Signaling Pathway and Its Role in Kidney Disease: An Update.Frontiers in immunology · 2017Review
- Article
- TGR5, Not Only a Metabolic Regulator.Frontiers in physiology · 2016Review
- Constitutive Stat3 activation alters behavior of hair follicle stem and progenitor cell populations.Molecular carcinogenesis · 2015Article
- Human herpesvirus 8 viral interleukin-6 signaling through gp130 promotes virus replication in primary effusion lymphoma and endothelial cells.Journal of virology · 2014Article
- IL-6 negatively regulates osteoblast differentiation through the SHP2/MEK2 and SHP2/Akt2 pathways in vitro.Journal of bone and mineral metabolism · 2014Article
- Article
- Overexpression of IL-10 in C2D macrophages promotes a macrophage phenotypic switch in adipose tissue environments.PloS one · 2014Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interleukin-6 (IL-6) induces growth arrest and macrophage differentiation through its receptor in a murine myeloid leukaemic cell line, M1, although it is largely unknown how the IL-6 receptor generates these signals. By using chimeric receptors consisting of the extracellular domain of growth hormone receptor and the transmembrane and cytoplasmic domain of gp130 with progressive C-terminal truncations, we showed that the membrane-proximal 133, but not 108, amino acids of gp130 could generate the signals for growth arrest, macrophage differentiation, down-regulation of c-myc and c-myb, induction of junB and IRF1 and Stat3 activation. Mutational analysis of this region showed that the tyrosine residue with the YXXQ motif was critical not only for Stat3 activation but also for growth arrest and differentiation, accompanied by down-regulation of c-myc and c-myb and immediate early induction of junB and IRF1. The tight correlation between Stat3 activation and other IL-6 functions was further observed in the context of the full-length cytoplasmic region of gp130. The result suggest that Stat3 plays an essential role in the signals for growth arrest and differentiation.
Indexed as
Identifiers
8612579PMC450065What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.