ArticleProceedings of the National Academy of Sciences of the United States of America1996
Mammalian ubiquitin-conjugating enzyme Ubc9 interacts with Rad51 recombination protein and localizes in synaptonemal complexes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
57 citing papers in PubMed, 162 citations in OpenAlex.
- Ubc9 Mediates SUMO2/3 Modification to Regulate Meiosis in Male Mice.Biomedicines · 2026Article
- The role of ubiquitin-conjugating enzyme in the process of spermatogenesis.Reproductive biology and endocrinology : RB&E · 2024Review
- TOPORS-mediated RAD51 SUMOylation facilitates homologous recombination repair.Nucleic acids research · 2022Article
- Depletion of DNA damage binding protein 2 sensitizes triple-negative breast cancer cells to poly ADP-ribose polymerase inhibition by destabilizing Rad51.Cancer science · 2019Article
- PIAS-family proteins negatively regulate Glis3 transactivation function through SUMO modification in pancreatic β cells.Heliyon · 2018Article
- Article
- Control of Meiotic Crossovers: From Double-Strand Break Formation to Designation.Annual review of genetics · 2016Review
- SUMO and SUMO-Conjugating Enzyme E2 UBC9 Are Involved in White Spot Syndrome Virus Infection in Fenneropenaeus chinensis.PloS one · 2016Article
- Depletion of UBC9 Causes Nuclear Defects during the Vegetative and Sexual Life Cycles in Tetrahymena thermophila.Eukaryotic cell · 2015Article
- Recombination, Pairing, and Synapsis of Homologs during Meiosis.Cold Spring Harbor perspectives in biology · 2015Review
- Starting and stopping SUMOylation. What regulates the regulator?Chromosoma · 2013Review
- New insights to the ubiquitin-proteasome pathway (UPP) mechanism during spermatogenesis.Molecular biology reports · 2013Review
- A novel small molecule RAD51 inactivator overcomes imatinib-resistance in chronic myeloid leukaemia.EMBO molecular medicine · 2013Article
- SUMOylation of pancreatic glucokinase regulates its cellular stability and activity.The Journal of biological chemistry · 2013Article
- Article
- SUMO Wrestles with Recombination.Biomolecules · 2012Article
- Homologous recombination and its regulation.Nucleic acids research · 2012Review
- The ubiquitin-proteasome system in cancer, a major player in DNA repair. Part 1: post-translational regulation.Journal of cellular and molecular medicine · 2009Review
- MicroRNA-mediated regulation of Ubc9 expression in cancer cells.Clinical cancer research : an official journal of the American Association for Cancer Research · 2009Article
- Developmental control of sumoylation pathway proteins in mouse male germ cells.Developmental biology · 2008Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Hsubc9, a human gene encoding a ubiquitin-conjugating enzyme, has been cloned. The 18-kDa HsUbc9 protein is homologous to the ubiquitin-conjugating enzymes Hus5 of Schizosaccharomyces pombe and Ubc9 of Saccharomyces cerevisiae. The Hsubc9 gene complements a ubc9 mutation of S. cerevisiae. It has been mapped to chromosome 16p13.3 and is expressed in many human tissues, with the highest levels in testis and thymus. According to the Ga14 two-hybrid system analysis, HsUbc9 protein interacts with human recombination protein Rad51. A mouse homolog, Mmubc9, encodes an amino acid sequence that is identical to the human protein. In mouse spermatocytes, MmUbc9 protein, like Rad51 protein, localizes in synaptonemal complexes, which suggests that Ubc9 protein plays a regulatory role in meiosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.