ArticleProceedings of the National Academy of Sciences of the United States of America1996
C factor, a cell-surface-associated intercellular signaling protein, stimulates the cytoplasmic Frz signal transduction system in Myxococcus xanthus.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 89 citations in OpenAlex.
- Mutation of self-binding sites in the promoter of the MrpC transcriptional regulator leads to asynchronousFrontiers in microbiology · 2023Article
- Cell density, alignment, and orientation correlate with C-signal-dependent gene expression duringProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- Ultrasensitive Response of Developing Myxococcus xanthus to the Addition of Nutrient Medium Correlates with the Level of MrpC.Journal of bacteriology · 2018Article
- Highly Signal-Responsive Gene Regulatory Network Governing Myxococcus Development.Trends in genetics : TIG · 2017Review
- How Myxobacteria Cooperate.Journal of molecular biology · 2015Review
- Short-range guiding can result in the formation of circular aggregates in myxobacteria populations.PLoS computational biology · 2015Article
- Article
- Myxococcus xanthus developmental cell fate production: heterogeneous accumulation of developmental regulatory proteins and reexamination of the role of MazF in developmental lysis.Journal of bacteriology · 2012Article
- High-force generation is a conserved property of type IV pilus systems.Journal of bacteriology · 2009Article
- Site-specific receptor methylation of FrzCD in Myxococcus xanthus is controlled by a tetra-trico peptide repeat (TPR) containing regulatory domain of the FrzF methyltransferase.Molecular microbiology · 2008Article
- Bacterial development in the fast lane.Journal of bacteriology · 2008Article
- EspA, an orphan hybrid histidine protein kinase, regulates the timing of expression of key developmental proteins of Myxococcus xanthus.Journal of bacteriology · 2008Article
- Combinatorial regulation of genes essential for Myxococcus xanthus development involves a response regulator and a LysR-type regulator.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Regulation of dev, an operon that includes genes essential for Myxococcus xanthus development and CRISPR-associated genes and repeats.Journal of bacteriology · 2007Article
- Regulation of the Myxococcus xanthus C-signal-dependent Omega4400 promoter by the essential developmental protein FruA.Journal of bacteriology · 2006Article
- Activation of a development-specific gene, dofA, by FruA, an essential transcription factor for development of Myxococcus xanthus.Journal of bacteriology · 2005Article
- A biochemical oscillator explains several aspects of Myxococcus xanthus behavior during development.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- TodK, a putative histidine protein kinase, regulates timing of fruiting body morphogenesis in Myxococcus xanthus.Journal of bacteriology · 2003Article
- Identification of the C-signal, a contact-dependent morphogen coordinating multiple developmental responses in Myxococcus xanthus.Genes & development · 2003Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
C factor, an intercellular signaling protein, is required for aggregation and sporulation of the social bacterium, Myxococcus xanthus. We report that C factor, which normally is associated with the cell surface, provides input to the Frz signal transduction cascade. Elements of this cascade have sequence homology to bacterial chemotaxis systems and are known to control the frequency of gliding reversal. Exposure of developing cells of a C-factor-less mutant (csgA) to purified C factor increases the ratio of methylated to nonmethylated FrzCD protein, the Frz homolog of the methyl-accepting chemotaxis proteins. Methylation depends on the cognate methyltransferase FrzF, and its extent increases with the concentration of C factor. C-factor-induced methylation also depends on the product of a gene, called class II, which is necessary in vivo for all known responses to C factor. A model for aggregation is proposed in which C factor stimulates the Frz cascade and thereby decreases cell reversals in a way that preferentially leads cells into an aggregate.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.