ArticleThe Journal of clinical investigation1996
Differentiated vascular myocytes: are they involved in neointimal formation?
Article in The Journal of clinical investigation, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 128 citations in OpenAlex.
- An update on clonality: what smooth muscle cell type makes up the atherosclerotic plaque?F1000Research · 2018Review
- Contribution of Vascular Cells to Neointimal Formation.PloS one · 2017Article
- The transition of smooth muscle cells from a contractile to a migratory, phagocytic phenotype: direct demonstration of phenotypic modulation.The Journal of physiology · 2016Article
- Origin and differentiation of vascular smooth muscle cells.The Journal of physiology · 2015Review
- Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap.PLoS genetics · 2015Article
- A Methodology for Concomitant Isolation of Intimal and Adventitial Endothelial Cells from the Human Thoracic Aorta.PloS one · 2015Article
- Hedgehog and Resident Vascular Stem Cell Fate.Stem cells international · 2015Review
- Adult vascular smooth muscle cells in culture express neural stem cell markers typical of resident multipotent vascular stem cells.Cell and tissue research · 2014Article
- Embryonic rat vascular smooth muscle cells revisited - a model for neonatal, neointimal SMC or differentiated vascular stem cells?Vascular cell · 2014Article
- TGF-β signaling mediates endothelial-to-mesenchymal transition (EndMT) during vein graft remodeling.Science translational medicine · 2014Article
- The adventitia: a progenitor cell niche for the vessel wall.Cells, tissues, organs · 2012Review
- Contributions of VEGF to age-dependent transmural gradients in contractile protein expression in ovine carotid arteries.American journal of physiology. Cell physiology · 2011Article
- The adventitia: a dynamic interface containing resident progenitor cells.Arteriosclerosis, thrombosis, and vascular biology · 2011Review
- Urotensin-II Immunoreactivity in Normolipidemic and Hyperlipidemic New Zealand White Rabbits Following Balloon Angioplasty and Stenting.International journal of biomedical science : IJBS · 2007Article
- In stent restenosis: bane of the stent era.Journal of clinical pathology · 2006Review
- Enhanced H(2)O(2)-induced cytotoxicity in "epithelioid" smooth muscle cells: implications for neointimal regression.Arteriosclerosis, thrombosis, and vascular biology · 2000Article
- A comparative molecular analysis of four rat smooth muscle cell lines.In vitro cellular & developmental biology. Animal · 1998Article
- Decreased vascular smooth muscle cell density in medial degeneration of human abdominal aortic aneurysms.The American journal of pathology · 1997Article
- Cellular retinol-binding protein-1 is expressed by distinct subsets of rat arterial smooth muscle cells in vitro and in vivo.The American journal of pathology · 1997Article
- Isolation and culture of the three vascular cell types from a small vein biopsy sample.In vitro cellular & developmental biology. AnimalArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The role of differentiated vascular myocytes are neointimal formation in canine carotid artery was investigated. Using antibodies and cDNA probes, cells were characterized in situ and after isolation. In situ characterization indicated the majority of medial cells expressed both smooth muscle myosin and alpha actin but many cells were negative to these markers. All adventitial cells were negative for these proteins. The muscle protein-positive cells were designated differentiated, vascular myocytes (VSMC). The others were designated type 2 cells. Sequential enzyme digestion from lumenal surface yielded VSMC ( > 90%) while digestions from the adventitial surface yielded type 2 cells ( > 90%). VSMC were viable in culture but did not spread, proliferate, or alter expression of muscle proteins. Type 2 cells proliferated and increased their expression of muscle actin but did not express muscle myosin. Characterization of neointimal cells from injured carotid arteries indicated they were morphologically and immunologically identical to cultured type 2 cells. We concluded that: (a) canine carotid artery media consists of a heterogeneous cell population: (b) serum does not stimulate isolated VSMC to undergo phenotypic modulation or proliferate: and (c) type 2 cells may be responsible for neointimal formation because they proliferate and acquire a phenotype identical to in situ neointimal cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.