ArticleThe Journal of clinical investigation1996
Genetic mapping of two blood pressure quantitative trait loci on rat chromosome 1.
Article in The Journal of clinical investigation, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 86 citations in OpenAlex.
- Shifting Paradigm from Gene Expressions to Pathways Reveals Physiological Mechanisms in Blood Pressure Control in Causation.International journal of molecular sciences · 2023Article
- Closely linked non-additive blood pressure quantitative trait loci.Mammalian genome : official journal of the International Mammalian Genome Society · 2008Article
- The kidney cytochrome P-450 2C23 arachidonic acid epoxygenase is upregulated during dietary salt loading.The Journal of clinical investigation · 1999Article
- Congenic strain confirms putative quantitative trait locus for body weight in the rat.Mammalian genome : official journal of the International Mammalian Genome Society · 1998Article
- Linkage mapping of rat chromosome markers generated from chromosome-sorted DNA.Mammalian genome : official journal of the International Mammalian Genome Society · 1998Article
- The cystatin S gene maps to rat chromosome 3, to which D1mgh18 is re-assigned from chromosome 1.Mammalian genome : official journal of the International Mammalian Genome Society · 1997Article
- A pharmacogenetic approach to blood pressure in Lyon hypertensive rats. A chromosome 2 locus influences the response to a calcium antagonist.The Journal of clinical investigation · 1997Article
- Rat chromosome 1: regional localization of seven genes (Slc9a3, Srd5a1, Esr, Tcp1, Grik5, Tnnt3, Jak2) and anchoring of the genetic linkage map to the cytogenetic map.Mammalian genome : official journal of the International Mammalian Genome Society · 1997Article
- Mapping of rat chromosome 5 markers generated from chromosome-sorted DNA.Mammalian genome : official journal of the International Mammalian Genome Society · 1997Article
- Comparative mapping of novel simple sequence repeat markers in a hypertension-related region on rat chromosome 1.Mammalian genome : official journal of the International Mammalian Genome Society · 1997Article
- Evidence of a non-MHC susceptibility locus in type I diabetes linked to HLA on chromosome 6.American journal of human genetics · 1997Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
A genetic map for rat chromosome 1 was constructed using 66 microsatellite markers typed on either or both of two populations derived from inbred Dahl salt-sensitive (S) rats: F2(LEW x S) n = 151, and F2(WKY x S) n = 159. These populations had been raised on a high salt (8% NaCl) diet. Systolic blood pressure and heart weight were found to be genetically linked to two separate regions on rat chromosome 1 in the F2(LEW x S) population. One region was centered around the anonymous SA locus and accounted for 24 mmHg of blood pressure. The other region was 55 cM from the SA locus centered around a cluster of cytochromes P450 loci, and accounted for 30 mmHg of blood pressure. Since blood pressure and heart weight were highly correlated these same regions were also linked to heart weight. These results were cross-specific as linkage of these chromosome 1 regions to blood pressure and heart weight was not observed in several other F2 populations derived by crossing S and other normotensive control strains. This is presumably due to different alleles and/or different genetic backgrounds in the various populations. The SA region of chromosome 1 was found to influence body weight in F2(LEW x S) rats. Combining the present data with our previously published data on the F2(LEW x S) population showed that four separate quantitative trait loci with additive effects accounted for 106 mmHg and 38% of the total variance of blood pressure and for 506 mg and 34% of the total variance of heart wt.
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