ArticleJournal of bacteriology1996
Amino acids induce expression of BAP2, a branched-chain amino acid permease gene in Saccharomyces cerevisiae.
Article in Journal of bacteriology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Structural bases of signal generation and transduction by the SPS amino acid sensor of Saccharomyces cerevisiae.G3 (Bethesda, Md.) · 2026Article
- The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum.FEBS letters · 2025Article
- Fitness landscape of substrate-adaptive mutations in evolved amino acid-polyamine-organocation transporters.eLife · 2024Article
- Sensing, Uptake and Catabolism of L-Phenylalanine During 2-Phenylethanol BiosynthesisFrontiers in microbiology · 2021Review
- The leucine biosynthetic pathway is crucial for adaptation to iron starvation and virulence inVirulence · 2019Article
- Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- UMAMIT14 is an amino acid exporter involved in phloem unloading in Arabidopsis roots.Journal of experimental botany · 2016Article
- L-Phenylalanine Transport in Saccharomyces cerevisiae: Participation of GAP1, BAP2, and AGP1.Journal of amino acids · 2014Article
- Influence of valine and other amino acids on total diacetyl and 2,3-pentanedione levels during fermentation of brewer's wort.Applied microbiology and biotechnology · 2013Article
- Regulation of amino acid, nucleotide, and phosphate metabolism in Saccharomyces cerevisiae.Genetics · 2012Article
- The Candida albicans GAP gene family encodes permeases involved in general and specific amino acid uptake and sensing.Eukaryotic cell · 2011Article
- The Penicillium chrysogenum extracellular proteome. Conversion from a food-rotting strain to a versatile cell factory for white biotechnology.Molecular & cellular proteomics : MCP · 2010Article
- Uga3 and Uga35/Dal81 transcription factors regulate UGA4 transcription in response to gamma-aminobutyric acid and leucine.Eukaryotic cell · 2010Article
- Amino acid transceptors: gate keepers of nutrient exchange and regulators of nutrient signaling.American journal of physiology. Endocrinology and metabolism · 2009Review
- Branched chain aldehydes: production and breakdown pathways and relevance for flavour in foods.Applied microbiology and biotechnology · 2009Review
- Effect of 21 different nitrogen sources on global gene expression in the yeast Saccharomyces cerevisiae.Molecular and cellular biology · 2007Article
- Competitive intra- and extracellular nutrient sensing by the transporter homologue Ssy1p.The Journal of cell biology · 2006Article
- Article
- Deletion of RTS1, encoding a regulatory subunit of protein phosphatase 2A, results in constitutive amino acid signaling via increased Stp1p processing.Eukaryotic cell · 2006Article
- Divergence of Stp1 and Stp2 transcription factors in Candida albicans places virulence factors required for proper nutrient acquisition under amino acid control.Molecular and cellular biology · 2005Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Branched-chain amino acid uptake in Saccharomyces cerevisiae is mediated by at least three transport systems: the general amino acid permease Gap1p, the branched-chain amino acid permease Bap2p, and one or more so far unknown permeases. Regulation of the transcription of BAP2 is mainly subject to the presence of certain amino acids in the medium. The level of transcription is low during growth on a minimal medium with proline as the sole nitrogen source. As assayed with a lacZ fusion, the level of transcription is slightly higher (3-fold) on a minimal medium with ammonium ions as a nitrogen source, and transcription is induced about 20-fold by addition of leucine (0.2 mM). As little as 10 microM leucine causes a fivefold induction. Addition of (L)-leucine to minimal proline medium, on the other hand, has no effect on BAP2 transcription. The two known permeases for transport of branched-chain amino acids, Gap1p and Bap2p, are thus not active at the same time. The BAP2 promoter contains one or two putative Gcn4p binding sites and one putative Leu3p binding site. None of the three is needed for induction by leucine. Induction of BAP2 transcription by leucine is accompanied by an increase in branched-chain amino acid uptake. This elevation is interpreted to be partly the result of an increased level of the Bap2p permease in the plasma membrane, because deletion of BAP2 slightly decreases the induction of uptake. There is still a leucine-inducible increase in branched-chain amino acid uptake in a delta gap1 delta bap2 strain, indicating that BAP2 shares leucine induction with at least one remaining branched-chain amino acid-transporting permease.
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