ArticleInfection and immunity1996
Vesicles containing Chlamydia trachomatis serovar L2 remain above pH 6 within HEC-1B cells.
Article in Infection and immunity, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 71 citations in OpenAlex.
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- Dynamic energy dependency ofThe Journal of biological chemistry · 2018Article
- TheFrontiers in cellular and infection microbiology · 2017Article
- Contrasting Lifestyles Within the Host Cell.Microbiology spectrum · 2016Review
- Modulation of host signaling and cellular responses by Chlamydia.Cell communication and signaling : CCS · 2013Review
- Article
- Characterization of the activity and expression of arginine decarboxylase in human and animal Chlamydia pathogens.FEMS microbiology letters · 2012Article
- Identification and functional analysis of CT069 as a novel transcriptional regulator in Chlamydia.Journal of bacteriology · 2011Article
- Regulation of chlamydial infection by host autophagy and vacuolar ATPase-bearing organelles.Infection and immunity · 2011Article
- Article
- Outer and inner membrane proteins compose an arginine-agmatine exchange system in Chlamydophila pneumoniae.Journal of bacteriology · 2008Article
- Novel Parachlamydia acanthamoebae quantification method based on coculture with amoebae.Applied and environmental microbiology · 2008Article
- Chlamydia trachomatis: genome sequence analysis of lymphogranuloma venereum isolates.Genome research · 2008Article
- Characterization of an acid-dependent arginine decarboxylase enzyme from Chlamydophila pneumoniae.Journal of bacteriology · 2007Article
- A live and inactivated Chlamydia trachomatis mouse pneumonitis strain induces the maturation of dendritic cells that are phenotypically and immunologically distinct.Infection and immunity · 2005Article
- Golgi-dependent transport of cholesterol to the Chlamydia trachomatis inclusion.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- In vitro and in vivo functional activity of Chlamydia MurA, a UDP-N-acetylglucosamine enolpyruvyl transferase involved in peptidoglycan synthesis and fosfomycin resistance.Journal of bacteriology · 2003Article
- Entry of the lymphogranuloma venereum strain of Chlamydia trachomatis into host cells involves cholesterol-rich membrane domains.Infection and immunity · 2003Article
- Interaction of Mycobacterium avium with human monocyte-derived dendritic cells.Infection and immunity · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Chlamydia trachomatis serovar L2 is an obligate intracellular bacterium which is internalized in target epithelial cells by endocytosis and resides within a membrane-bound vesicle. Over the next several hours following entry, individual serovar L2-containing vesicles fuse with one another to form a single membrane-bound vesicle (or inclusion) within which the microcolony develops. The experiments reported here directly examined the pH of vesicles containing chlamydiae. The pH was determined by measuring emission ratios of the fluorescent, pH-sensitive probe SNAFL (5-[and 6-]-carboxyseminaphthofluorescein-1, succinimidyl ester) conjugated to chlamydiae. The pH remained above 6.0 at 2, 4, and 12 h after infection, while the pH of vesicles contained heat-killed organisms fell 5.3. In the presence of amines, which raise the pH of acidic compartments, C. trachomatis inclusion formation was unaffected. Inactivation of Na+,K+ -ATPases, the ion pumps responsible for maintaining a pH above 6 within early endocytic vesicles, inhibited the growth of C. trachomatis within epithelial cells. Preventing vesicular acidification by inhibiting the vacuolar proton ATPase did not affect chlamydial growth. Thus, chlamydiae do not reside within highly acidic vesicles and avoid the pathway leading to lysosomes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.