ArticleImmunogenetics1996
Sequence analysis of a polymorphic Mhc class II gene in Pacific salmon.
Article in Immunogenetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 94 citations in OpenAlex.
- Evaluating the Potential Fitness Effects of Chinook Salmon (Animals : an open access journal from MDPI · 2023Article
- Differential patterns of diversity at neutral and adaptive loci in endangered Rhodeus pseudosericeus populations.Scientific reports · 2021Article
- Fate of MHCII in salmonids following 4WGD.Immunogenetics · 2021Article
- Polymorphism of MHC class IIB in an acheilognathid species, Rhodeus sinensis shaped by historical selection and recombination.BMC genetics · 2019Article
- Article
- MHC and Evolution in Teleosts.Biology · 2016Review
- Genetics and genomics of disease resistance in salmonid species.Frontiers in genetics · 2014Review
- Molecular cloning and expression analysis of major histocompatibility complex class IIB gene of the Whitespotted bambooshark (Chiloscyllium plagiosum).Fish physiology and biochemistry · 2013Article
- Structure, diversity and evolutionary patterns of expressed MHC class IIB genes in chub (Squalius cephalus), a cyprinid fish species from Europe.Immunogenetics · 2011Article
- Single nucleotide polymorphisms unravel hierarchical divergence and signatures of selection among Alaskan sockeye salmon (Oncorhynchus nerka) populations.BMC evolutionary biology · 2011Article
- MHC evolution in three salmonid species: a comparison between class II alpha and beta genes.Immunogenetics · 2010Article
- Sexual conflict inhibits female mate choice for major histocompatibility complex dissimilarity in Chinook salmon.Proceedings. Biological sciences · 2010Article
- Divergent patterns of selection on the DAB and DXB MHC class II loci in Xiphophorus fishes.Genetica · 2009Article
- Patterns of historical balancing selection on the salmonid major histocompatibility complex class II beta gene.Journal of molecular evolution · 2007Article
- The salmonid MHC class I: more ancient loci uncovered.Immunogenetics · 2006Article
- Major histocompatibility genes in the Lake Tana African large barb species flock: evidence for complete partitioning of class II B, but not class I, genes among different species.Immunogenetics · 2005Article
- Applications of selective neutrality tests to molecular ecology.Molecular ecology · 2002Review
- Article
- Article
- Evidence for balancing selection operating at the het-c heterokaryon incompatibility locus in a group of filamentous fungi.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polymorphism of the nucleotide sequences encoding 149 amino acids of linked major histocompatibility complex (Mhc) class II B1 and B2 peptides, and of the intervening intron (548-773 base pairs), was examined within and among seven Pacific salmon (Oncorhynchus) species. Levels of nucleotide diversity were higher for the B1 sequence than for B2 or the intron in comparisons both within and between species. For the codons of the peptide binding region of the B1 sequence, the level of nonsynonymous nucleotide substitution (dN) exceeded the level of synonymous substitution (dS) by a factor of ten for within-species comparisons, and by a factor of four for between-species comparisons. The excess of dN indicates that balancing selection maintains diversity at this salmonid Mhc class II locus, as is common for Mhc loci in other vertebrates. Levels of nucleotide diversity for both the exon and intron sequences were greater among than within species, and there were numerous species-specific nucleotides present in both the coding and noncoding regions. Thus, neighbor-joining analysis of both the intron and exon regions provided phylogenies in which the sequences clustered strongly by species. There was little evidence of shared ancestral (trans-species) polymorphism in the exon phylogeny, and the intron phylogeny depicted standard relationships among the Pacific salmon species. The lack of shared allelic B1 lineages in these closely related species may result from severe bottlenecks that occurred during speciation or during the ice ages that glaciated the rim of the north Pacific Ocean approximately every 100000 years in the Pleistocene.
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