ArticleThe EMBO journal1996
Chromatin binding, nuclear localization and phosphorylation of Xenopus cdc21 are cell-cycle dependent and associated with the control of initiation of DNA replication.
Article in The EMBO journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 113 citations in OpenAlex.
- RNAs coordinate nuclear envelope assembly and DNA replication through ELYS recruitment to chromatin.Nature communications · 2017Article
- DNA replication origin activation in space and time.Nature reviews. Molecular cell biology · 2015Review
- Genomic instability in cancer.Cold Spring Harbor perspectives in biology · 2013Review
- KDM5B regulates embryonic stem cell self-renewal and represses cryptic intragenic transcription.The EMBO journal · 2011Article
- Geminin stabilizes Cdt1 during meiosis in Xenopus oocytes.The Journal of biological chemistry · 2009Article
- Dynamic localization of the DNA replication proteins MCM5 and MCM7 in plants.Plant physiology · 2009Article
- Replication initiation complex formation in the absence of nuclear function in Xenopus.Nucleic acids research · 2009Article
- DNA replication and progression through S phase.Oncogene · 2005Review
- Cyclin/CDK regulates the nucleocytoplasmic localization of the human papillomavirus E1 DNA helicase.Journal of virology · 2004Article
- Deregulation of cyclin E in human cells interferes with prereplication complex assembly.The Journal of cell biology · 2004Article
- Eukaryotic MCM proteins: beyond replication initiation.Microbiology and molecular biology reviews : MMBR · 2004Review
- Association between histology grade, expression of HsMCM2, and cyclin A in human invasive breast carcinomas.Journal of clinical pathology · 2003Article
- Article
- Drosophila minichromosome maintenance 6 is required for chorion gene amplification and genomic replication.Molecular biology of the cell · 2002Article
- Limiting DNA replication to once and only once.EMBO reports · 2000Review
- Distinct phosphoisoforms of the Xenopus Mcm4 protein regulate the function of the Mcm complex.Molecular and cellular biology · 2000Article
- Sequential MCM/P1 subcomplex assembly is required to form a heterohexamer with replication licensing activity.The Journal of biological chemistry · 2000Article
- The human autoantigen MCP1 is required during early stages of DNA replication.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2000Article
- Regulated formation of extrachromosomal circular DNA molecules during development in Xenopus laevis.Molecular and cellular biology · 1999Article
- MCM proteins are associated with RNA polymerase II holoenzyme.Molecular and cellular biology · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A Xenopus homologue of Schizosaccharomyces pombe cdc21 has been characterized as a new member of the MCM family of proteins. The cdc21 protein exhibits cell-cycle dependent chromatin binding and phosphorylation in association with S-phase control. Cdc21 binds to decondensing chromatin at the end of mitosis, localizing to numerous foci which form prior to reconstitution of the nuclear membrane. The association of cdc21 with chromatin occurs in membrane-free high speed extracts and is resistant to detergent extraction. The spatial organization of the cdc21 foci resembles that of pre-replication centres though no co-localization with RP-A was observed. Cdc21 remains bound to chromatin during the initiation of DNA replication and is displaced as the DNA replication forks progress. These subnuclear changes in localization correlate with cell-cycle-regulated changes in phosphorylation. Cdc21 binds to chromatin in an underphosphorylated state, but in early S phase the nuclear localized cdc21 is partially phosphorylated before it is displaced from the chromatin. Cytoplasmic cdc21 remains underphosphorylated but at the beginning of mitosis the entire pool of cdc21 is hyperphosphorylated, possibly by the cdc2/cyclin B kinase. These properties identify Xenopus cdc21 as a possible component of the DNA licensing factor.
Indexed as
Identifiers
8605878PMC450006W1443722688What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.