ReviewVirchows Archiv : an international journal of pathology1996
Islet cell neogenesis in the pancreas.
Review in Virchows Archiv : an international journal of pathology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Regulation of pancreatic beta-cell mass and its importance for antidiabetic therapies.Journal of molecular medicine (Berlin, Germany) · 2026Article
- Arginine 65 methylation of Neurogenin 3 by PRMT1 is required for pancreatic endocrine development of hESCs.Experimental & molecular medicine · 2023Article
- Navigating the Depths and Avoiding the Shallows of Pancreatic Islet Cell Transcriptomes.Diabetes · 2019Article
- (Re)generating Human Beta Cells: Status, Pitfalls, and Perspectives.Physiological reviews · 2018Review
- Decoding the Molecular and Mutational Ambiguities of Gastroenteropancreatic Neuroendocrine Neoplasm Pathobiology.Cellular and molecular gastroenterology and hepatology · 2015Review
- Article
- Development and regeneration in the endocrine pancreas.ISRN endocrinology · 2012Article
- The diversity and commonalities of gastroenteropancreatic neuroendocrine tumors.Langenbeck's archives of surgery · 2011Review
- Pancreatic beta-cells: from generation to regeneration.Seminars in cell & developmental biology · 2010Review
- Mechanisms of KGF mediated signaling in pancreatic duct cell proliferation and differentiation.PloS one · 2009Article
- Article
- Beneficial effects of L-arginine nitric oxide-producing pathway in rats treated with alloxan.The Journal of physiology · 2007Article
- Diabetes mellitus: a risk factor for pancreatic cancer?Langenbeck's archives of surgery · 2005Review
- Expression of progenitor cell markers during expansion of sorted human pancreatic beta cells.Gene expression · 2005Article
- In vitro generation of insulin-producing beta cells from adult exocrine pancreatic cells.Diabetologia · 2005Article
- A pentadecapeptide fragment of islet neogenesis-associated protein increases beta-cell mass and reverses diabetes in C57BL/6J mice.Annals of surgery · 2004Article
- Advances in diabetes for the millennium: toward a cure for diabetes.MedGenMed : Medscape general medicine · 2004Review
- Combined gastrin and epidermal growth factor treatment induces islet regeneration and restores normoglycaemia in C57Bl6/J mice treated with alloxan.Diabetologia · 2004Article
- Characterization of the abnormal pancreatic development, reduced growth and infertility in Cdk4 mutant mice.Oncogene · 2003Article
- Keratinocyte growth factor and beta-cell differentiation in human fetal pancreatic endocrine precursor cells.Diabetologia · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The beta cell population of the endocrine pancreas may expand by either of two processes, neogenesis or replication. While replication requires the existence of an already differentiated beta cell, neogenesis depends on the presence of active stem cells. Since the replicative activity of highly specialized cells such as beta cells seems to be limited, it is interesting to study the potential of the endocrine pancreas for beta cell neogenesis. In this article we review both the current state of knowledge of beta cell neogenesis under natural conditions and in response to stimulation, and the significance of neogenesis for beta cell growth in health and disease.
Indexed as
Identifiers
8605565What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.