ArticleBritish journal of cancer1996
Bone morphogenetic protein type IB receptor is progressively expressed in malignant glioma tumours.
Article in British journal of cancer, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 38 citations in OpenAlex.
- Targeting the dual miRNA/BMP2 network: LncRNA H19-mediated temozolomide resistance unveils novel therapeutic strategies in glioblastoma.Frontiers in oncology · 2025Article
- Molecular signature of stem-like glioma cells (SLGCs) from human glioblastoma and gliosarcoma.PloS one · 2024Article
- Identification of miRNA signature associated with BMP2 and chemosensitivity of TMZ in glioblastoma stem-like cells.Genes & diseases · 2020Article
- Bone morphogenetic protein signaling promotes tumorigenesis in a murine model of high-grade glioma.Neuro-oncology · 2016Article
- Genomic Analysis of the BMP Family in Glioblastomas.Translational oncogenomics · 2015Article
- Snail depletes the tumorigenic potential of glioblastoma.Oncogene · 2013Article
- Therapy targets in glioblastoma and cancer stem cells: lessons from haematopoietic neoplasms.Journal of cellular and molecular medicine · 2013Review
- Non-invasive neural stem cells become invasive in vitro by combined FGF2 and BMP4 signaling.Journal of cell science · 2013Article
- Massive human co-expression network and its medical applications.Chemistry & biodiversity · 2012Article
- Imaging bone morphogenetic protein 7 induced cell cycle arrest in experimental gliomas.Neoplasia (New York, N.Y.) · 2011Article
- Bone morphogenetic protein 4 (BMP4) signaling in retinoblastoma cells.International journal of biological sciences · 2010Article
- Constitutive activation of BMP signalling abrogates experimental metastasis of OVCA429 cells via reduced cell adhesion.Journal of ovarian research · 2010Article
- Loss of expression of bone morphogenetic protein receptor type II in human prostate cancer cells.Oncogene · 2004Article
- Sequential actions of BMP receptors control neural precursor cell production and fate.Genes & development · 2001Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The distribution of bone morphogenetic protein (BMP) type I receptors and the activin type I receptor (ActR-I) was investigated in 16 cases of human glioma and five cases of non-tumourous gliosis tissue by immunohistochemical technique. Both BMP type IA (BMPR-IA) and the type IB (BMPR-IB) receptors were detected in human glioma cells. A significant increase in BMPR-IB in tumour cells was observed in malignant glioma compared with both low-grade astrocytomas (n=16, P<0.005) and gliosis (n=13, P<0.001). However, enhancement of BMPR-IA staining was moderate and ActR-I staining was only weakly expressed in the malignant glioma tumours. Osteogenic protein (OP)-1/BMP-7, which is known to bind BMPR-IA, BMPR-IB and ActR-I, was expressed in nervous tissue and was also detected in anaplastic areas of malignant glioma. In contrast to the tissue materials, BMPR-IA was expressed to a stronger degree than BMPR-IB in human glioma cell lines; the growth of these cells was suppressed by OP-1. These results suggest the presence of BMP receptors and a functional role for BMPs in malignant glioma.
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