ArticleBritish journal of cancer1996
c-erbB-2 in astrocytomas: infrequent overexpression by immunohistochemistry and absence of gene amplification by fluorescence in situ hybridization.
Article in British journal of cancer, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- Article
- An immunohistochemical study of HER2 expression in primary brain tumors.BioMedicine · 2020Article
- IGFBP2 potentiates nuclear EGFR-STAT3 signaling.Oncogene · 2016Article
- c-erbB-2 protein expression in astrocytic tumors of the brain.Medical science monitor : international medical journal of experimental and clinical research · 2011Article
- Article
- Overexpression of c-erbB2 is a negative prognostic factor in anaplastic astrocytomas.Diagnostic pathology · 2010Article
- Targets for active immunotherapy against pediatric solid tumors.Cancer immunology, immunotherapy : CII · 2009Review
- Low HER2-expressing glioblastomas are more often secondary to anaplastic transformation of low-grade glioma.Journal of neuro-oncology · 2007Article
- Expression of antioxidant enzymes in astrocytic brain tumors.Brain pathology (Zurich, Switzerland) · 2003Article
- Growth factors in glioma angiogenesis: FGFs, PDGF, EGF, and TGFs.Journal of neuro-oncologyReview
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies suggest that aberrations of c-erbB-2 may be involved in astrocytic brain tumours. We screened immunohistochemically c-erbB2 protein (p185) expression in 94 astrocytic grade 1-4 neoplasms of the brain. The amplification of the c-erbB-2 oncogene was investigated in protein overexpression cases by dual colour fluorescence in situ hybridisation (FISH). p185 overexpression was correlated with p53 and epidermal growth factor receptor (EGFR) expression, as well as with clinicopathological features. Only two anaplastic (grade 3) astrocytomas and one glioblastoma (grade 4) showed overexpression of p185 protein by immunohistochemistry (monoclonal MAb1 antibody TA250), whereas none of the grade 1-2 astrocytomas was positive. Interestingly, the expression of p185 was confined solely to the cytoplasm of neoplastic astrocytic cells and not to the cell membranes as found in malignancies with amplification of the c-erbB-2 oncogene. Two of the three overexpression cases were also positive by EGFR. No amplification of the c-erbB-2 gene was observed by FISH in the three tumours with immunohistochemical p185 overexpression or seven weakly positive/negative tumours. In conclusion, our results suggest that p185 overexpression is infrequent in astrocytomas, that it is of no important diagnostic or prognostic value and that c-erbB-2 oncogene amplification is not seen in the few cases in which there is overexpression.
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