ArticleNucleic acids research1996
Phosphorylation of p53 at the casein kinase II site selectively regulates p53-dependent transcriptional repression but not transactivation.
Article in Nucleic acids research, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 74 citations in OpenAlex.
- TNFAIP8 modulates the survival and immune activity of Th17 cells via p53/ p21/ MDM2 pathway after acute insult.Cytokine: X · 2022Article
- Casein kinase II activates Bik to induce death of hyperplastic mucous cells in a cell cycle-dependent manner.Journal of cellular physiology · 2022Article
- The potential mechanism of extracellular high mobility group box-1 protein mediated p53 expression in immune dysfunction of T lymphocytes.Oncotarget · 2017Article
- Role of Bcl-xL/Beclin-1 in synergistic apoptotic effects of secretory TRAIL-armed adenovirus in combination with mitomycin C and hyperthermia on colon cancer cells.Apoptosis : an international journal on programmed cell death · 2014Article
- Molecular cloning and expression of a bush related CmV1 gene in tropical pumpkin.Molecular biology reports · 2010Article
- Role of p53, PUMA, and Bax in wogonin-induced apoptosis in human cancer cells.Biochemical pharmacology · 2008Article
- Posttranslational phosphorylation of mutant p53 protein in tumor development.Medical molecular morphology · 2006Review
- Increased sensitivity to UV radiation in mice with a p53 point mutation at Ser389.Molecular and cellular biology · 2004Article
- p53-dependent and p53-independent pathways for radiation-induced immature thymocyte differentiation.Oncogene · 2004Article
- NF-kappaB prevents cells from undergoing Cr(VI)-induced apoptosis.Molecular and cellular biochemistry · 2004Article
- Hypoxia attenuates the p53 response to cellular damage.Oncogene · 2003Article
- Protein kinase CK2 is involved in G2 arrest and apoptosis following spindle damage in epithelial cells.Oncogene · 2001Article
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- Increased p53 phosphorylation after microtubule disruption is mediated in a microtubule inhibitor- and cell-specific manner.Oncogene · 2001Article
- Glycerol restores p53-dependent radiosensitivity of human head and neck cancer cells bearing mutant p53.British journal of cancer · 2000Article
- Inactivation of p53 by human T-cell lymphotropic virus type 1 Tax requires activation of the NF-kappaB pathway and is dependent on p53 phosphorylation.Molecular and cellular biology · 2000Article
- Regulation of p53 in response to DNA damage.Oncogene · 1999Review
- hMutSalpha- and hMutLalpha-dependent phosphorylation of p53 in response to DNA methylator damage.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
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Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The p53 tumour suppressor protein is a potent transcription factor which plays a central role in the defence of cells against DNA damage and the propagation of malignant clones. We have previously shown that phosphorylation of serine 386 in mouse p53 by the growth- associated protein kinase, casein kinase II (CKII), plays an important role in the ability of p53 to block the proliferation of drug-resistant colonies. In this paper we show that blocking phosphorylation of serine 386 through an alanine substitution, or placing a constitutive negative charge at this position in the form of aspartate, had no significant influence on p53-dependent transcriptional activation of a promoter containing 13 copies of a p53 consensus binding sequence, or of the p21WAF1 promoter which is a natural target for p53. In contrast, the alanine mutant showed a weak reduction in the ability of p53 to repress expression from the c-fos promoter, which is a target for p53-dependent repression in vivo. Strikingly, when the repression of the SV40 early promoter was examined, a reduction in the repression capacity of up to 5-fold was observed. Moreover, repression of the SV40 promoter could be partially restored by aspartic acid substitution at the phosphorylation site. These data indicate that phosphorylation at a specific C-terminal site can selectively regulate p53-dependent repression, but not transactivation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.