ArticleNucleic acids research1996
During in vivo maturation of eukaryotic nuclear mRNA, splicing yields excised exon circles.
Article in Nucleic acids research, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 45 citations in OpenAlex.
- Mechanism of Action of circRNA/miRNA Network in DLBCL.Non-coding RNA · 2025Review
- Recent advances and perspectives on the development of circular RNA cancer vaccines.NPJ vaccines · 2025Review
- Translation of Circular RNAs: Functions of Translated Products and Related Bioinformatics Approaches.Current bioinformatics · 2024Article
- Biological functions of circRNAs and their advance on skeletal muscle development in bovine.3 Biotech · 2023Review
- Circular RNA in Multiple Sclerosis: Pathogenicity and Potential Biomarker Development: A Systematic Review.Epigenetics insights · 2023Review
- Screening differential circular RNAs expression profiles in Vulvar Lichen Sclerosus.Biomedical engineering online · 2022Article
- Circular RNAs in kidney disease and cancer.Nature reviews. Nephrology · 2021Review
- The Emerging Roles of circFOXO3 in Cancer.Frontiers in cell and developmental biology · 2021Review
- Circular RNAs in Hematopoiesis with a Focus on Acute Myeloid Leukemia and Myelodysplastic Syndrome.International journal of molecular sciences · 2020Review
- Role of circular RNAs in brain development and CNS diseases.Progress in neurobiology · 2020Review
- CircRNAFisher: a systematic computational approach for de novo circular RNA identification.Acta pharmacologica Sinica · 2019Article
- Functional Characterization of Novel Circular RNA Molecule, circzip-2 and Its Synthesizing Gene zip-2 in C. elegans Model of Parkinson's Disease.Molecular neurobiology · 2018Article
- Article
- Circular RNAs: the Emerging Class of Non-coding RNAs and Their Potential Role in Human Neurodegenerative Diseases.Molecular neurobiology · 2017Review
- Circular RNA has_circ_0067934 is upregulated in esophageal squamous cell carcinoma and promoted proliferation.Scientific reports · 2016Article
- CircRNAs in hematopoiesis and hematological malignancies.Blood cancer journal · 2016Review
- Circular RNA Expression: Its Potential Regulation and Function.Trends in genetics : TIG · 2016Review
- Circular RNAs: Novel Regulators of Neuronal Development.Frontiers in molecular neuroscience · 2016Review
- Circular RNAs in Eukaryotic Cells.Current genomics · 2015Article
- A view of pre-mRNA splicing from RNase R resistant RNAs.International journal of molecular sciences · 2014Review
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Circular splicing has already been described on nuclear pre-mRNA for certain splice sites far apart in the multi exonic ETS-1 gene and in the single 1.2 kb exon of the Sry locus. To date, it is unclear how splice site juxtaposition occurs in normal and circular splicing. The splice site selection of an internal exon is likely to involve pairing between splice sites across that exon. Based on this, we predict that, albeit at low frequency, internal exons yield circular RNA by splicing as an error-prone mechanism of exon juxtaposition or, perhaps more interestingly, as a regulated mechanism on alternative exons. To address this question, the circular exon formation was analyzed at three ETS-1 internal exons (one alternative spliced exon and two constitutive), in human cell line and blood cell samples. Here, we show by RT-PCR and sequencing that exon circular splicing occurs at the three individual exons that we examined. RNase protection experiments suggest that there is no correlation between exon circle expression and exon skipping.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.