ArticleNucleic acids research1996
Binding site analysis of c-Myb: screening of potential binding sites by using the mutation matrix derived from systematic binding affinity measurements.
Article in Nucleic acids research, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 37 citations in OpenAlex.
- Leprosy drug clofazimine activates peroxisome proliferator-activated receptor-γ and synergizes with imatinib to inhibit chronic myeloid leukemia cells.Haematologica · 2020Article
- Reading More than Histones: The Prevalence of Nucleic Acid Binding among Reader Domains.Molecules (Basel, Switzerland) · 2018Review
- Silencing of an α-dioxygenase gene, Ca-DOX, retards growth and suppresses basal disease resistance responses in Capsicum annum.Plant molecular biology · 2017Article
- c-MYB is a transcriptional regulator of ESPL1/Separase in BCR-ABL-positive chronic myeloid leukemia.Biomarker research · 2016Article
- Identification, isolation, and expression analysis of heat shock transcription factors in the diploid woodland strawberry Fragaria vesca.Frontiers in plant science · 2015Article
- The conserved transcription factors, MYB115 and MYB118, control expression of the newly evolved benzoyloxy glucosinolate pathway in Arabidopsis thaliana.Frontiers in plant science · 2015Article
- Mutation signature of adenoid cystic carcinoma: evidence for transcriptional and epigenetic reprogramming.The Journal of clinical investigation · 2013Article
- An ancient transcription factor initiates the burst of piRNA production during early meiosis in mouse testes.Molecular cell · 2013Article
- Endogenous retrovirus-K promoter: a landing strip for inflammatory transcription factors?Retrovirology · 2013Review
- A conserved molecular mechanism is responsible for the auto-up-regulation of glucocorticoid receptor gene promoters.Molecular endocrinology (Baltimore, Md.) · 2008Article
- Genome-wide identification of the regulatory targets of a transcription factor using biochemical characterization and computational genomic analysis.BMC bioinformatics · 2005Article
- The human neuroendocrine thyrotropin-releasing hormone receptor promoter is activated by the haematopoietic transcription factor c-Myb.The Biochemical journal · 2003Article
- Alteration of C-MYB DNA binding to cognate responsive elements in HL-60 variant cells.Molecular pathology : MP · 2002Article
- A novel yeast system for in vivo selection of recognition sequences: defining an optimal c-Myb-responsive element.Nucleic acids research · 2001Article
- Quantitative parameters for amino acid-base interaction: implications for prediction of protein-DNA binding sites.Nucleic acids research · 1998Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The c-Myb oncoprotein is known to bind to multiple sites in the promoters of target genes. We have developed a protocol to screen the binding site of c-Myb by using the systematic binding data derived form measurements of binding affinity for oligonucleotide containing a known Myb-binding site and its complete single mutants. We first applied the method to predict the binding affinity for the known binding sites and compared with available experimental data. The predicated binding sites agree with many putative binding sites of known target promoters. However, there are some binding sites not predicated by the analysis. These sequences deviate from the consensus sequence derived from the binding analyses. In the light of the structure of Myb-DNA complex, these results indicate that different DNA-binding modes may be used by c-Myb to recognize different classes of binding sites. We also screened the sequence database for potential Myb-binding sites, and found sequences of several promoters that have not been identified experimentally but could be the target for c-Myb.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.