ArticleNucleic acids research1996
Binding to the yeast SwI4,6-dependent cell cycle box, CACGAAA, is cell cycle regulated in vivo.
Article in Nucleic acids research, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
- Regulation of conidiation, dimorphic transition, and microsclerotia formation by MrSwi6 transcription factor in dimorphic fungus Metarhizium rileyi.World journal of microbiology & biotechnology · 2019Article
- Identification of yeast cell cycle regulated genes based on genomic features.BMC systems biology · 2013Article
- Deconvolution of chromatin immunoprecipitation-microarray (ChIP-chip) analysis of MBF occupancies reveals the temporal recruitment of Rep2 at the MBF target genes.Eukaryotic cell · 2011Article
- The transcriptional network activated by Cln3 cyclin at the G1-to-S transition of the yeast cell cycle.Genome biology · 2010Article
- The E2F functional analogue SBF recruits the Rpd3(L) HDAC, via Whi5 and Stb1, and the FACT chromatin reorganizer, to yeast G1 cyclin promoters.The EMBO journal · 2009Article
- Linking cell cycle to histone modifications: SBF and H2B monoubiquitination machinery and cell-cycle regulation of H3K79 dimethylation.Molecular cell · 2009Article
- Recruitment of Cln3 cyclin to promoters controls cell cycle entry via histone deacetylase and other targets.PLoS biology · 2009Article
- Stb1 collaborates with other regulators to modulate the G1-specific transcriptional circuit.Molecular and cellular biology · 2008Article
- Rb, whi it's not just for metazoans anymore.Oncogene · 2006Review
- Regulation of the cell cycle by protein phosphatase 2A in Saccharomyces cerevisiae.Microbiology and molecular biology reviews : MMBR · 2006Review
- Cell wall integrity signaling in Saccharomyces cerevisiae.Microbiology and molecular biology reviews : MMBR · 2005Review
- Clb6/Cdc28 and Cdc14 regulate phosphorylation status and cellular localization of Swi6.Molecular and cellular biology · 2004Article
- G1 transcription factors are differentially regulated in Saccharomyces cerevisiae by the Swi6-binding protein Stb1.Molecular and cellular biology · 2003Article
- Complex transcriptional circuitry at the G1/S transition in Saccharomyces cerevisiae.Genes & development · 2002Article
- The G(1) cyclin Cln3 promotes cell cycle entry via the transcription factor Swi6.Molecular and cellular biology · 2002Article
- Transcriptional coregulation by the cell integrity mitogen-activated protein kinase Slt2 and the cell cycle regulator Swi4.Molecular and cellular biology · 2001Article
- Early cell cycle box-mediated transcription of CLN3 and SWI4 contributes to the proper timing of the G(1)-to-S transition in budding yeast.Molecular and cellular biology · 2001Article
- Ash1p is a site-specific DNA-binding protein that actively represses transcription.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Genetic analysis of the shared role of CLN3 and BCK2 at the G(1)-S transition in Saccharomyces cerevisiae.Genetics · 1999Article
- Cell cycle-regulated transcription in fission yeast: Cdc10-Res protein interactions during the cell cycle and domains required for regulated transcription.Molecular biology of the cell · 1999Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Saccharomyces cerevisiae commitment to cell division occurs late in the G1 phase of the cell cycle at a point called Start and requires the activity of the Cdc28 protein kinase and its associated G1 cyclins. The Swi4,6-dependent cell cycle box binding factor, SBF, is important for maximal expression of the G1 cyclin and HO endonuclease genes at Start. The cell cycle regulation of these genes is modulated through an upstream regulatory element termed the SCB (SwI4,6-dependent cell cycle box, CACGAAA), which is dependent on both SWI4 and SWI6. Although binding of SWI4 and SWI6 to SCB sequences has been well characterized in vitro, the binding of SBF in vivo has not been examined. We used in vivo dimethyl sulfate footprinting to examine the occupancy of SCB sequences throughout the cell cycle. We found that binding to SCB sequences occurred in the G1 phase of the cell cycle and was greatly reduced in G2. In the absence of either SWI4 or SWI6, SCB sequences were not occupied at any cell cycle stage. These results suggest that the G1-specific expression of SCB-dependent genes is regulated at the level of DNA binding in vivo.
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