ArticleThe Journal of cell biology1996
Gene targeting at the mouse cytokeratin 10 locus: severe skin fragility and changes of cytokeratin expression in the epidermis.
Article in The Journal of cell biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 94 citations in OpenAlex.
- Targeting SERCA2 in organotypic epidermis reveals MEK inhibition as a therapeutic strategy for Darier disease.JCI insight · 2023Article
- Dermal Exposure to the Immunomodulatory Antimicrobial Chemical Triclosan Alters the Skin Barrier Integrity and Microbiome in Mice.Toxicological sciences : an official journal of the Society of Toxicology · 2021Article
- The Impact of Proteomic Investigations on the Development and Improvement of Skin Laser Therapy: A Review Article.Journal of lasers in medical sciences · 2019Review
- Wild-type and SAMP8 mice show age-dependent changes in distinct stem cell compartments of the interfollicular epidermis.PloS one · 2019Article
- Keratin14 mRNA expression in human pneumocytes during quiescence, repair and disease.PloS one · 2017Article
- Loss of keratin K2 expression causes aberrant aggregation of K10, hyperkeratosis, and inflammation.The Journal of investigative dermatology · 2014Article
- The expanding significance of keratin intermediate filaments in normal and diseased epithelia.Current opinion in cell biology · 2013Review
- STAT3 signal transduction through interleukin-22 in oral squamous cell carcinoma.International journal of oncology · 2012Article
- Genetically engineered mouse models for skin research: taking the next step.Journal of dermatological science · 2008Review
- The human keratins: biology and pathology.Histochemistry and cell biology · 2008Review
- Discovery of a novel murine keratin 6 (K6) isoform explains the absence of hair and nail defects in mice deficient for K6a and K6b.The Journal of cell biology · 2001Article
- Complete cytolysis and neonatal lethality in keratin 5 knockout mice reveal its fundamental role in skin integrity and in epidermolysis bullosa simplex.Molecular biology of the cell · 2001Article
- Formation of a normal epidermis supported by increased stability of keratins 5 and 14 in keratin 10 null mice.Molecular biology of the cell · 2001Article
- Targeted deletion of keratins 18 and 19 leads to trophoblast fragility and early embryonic lethality.The EMBO journal · 2000Article
- Delayed wound healing in keratin 6a knockout mice.Molecular and cellular biology · 2000Article
- Cytokeratin 8 protects from hepatotoxicity, and its ratio to cytokeratin 18 determines the ability of hepatocytes to form Mallory bodies.The American journal of pathology · 2000Article
- Skin innate immune system in psoriasis: friend or foe?The Journal of clinical investigation · 1999Review
- The functional diversity of epidermal keratins revealed by the partial rescue of the keratin 14 null phenotype by keratin 16.The Journal of cell biology · 1999Article
- Functional differences between keratins of stratified and simple epithelia.The Journal of cell biology · 1998Article
- Directed expression of keratin 16 to the progenitor basal cells of transgenic mouse skin delays skin maturation.The Journal of cell biology · 1998Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Bullous congenital ichthyosiform erythroderma (BCIE) is a dominantly inherited blistering skin disorder caused by point mutations in the suprabasal cytokeratins 1 or 10. Targeting the murine cytokeratin 10 gene in ES cells resulted in mice with different phenotypes in the homozygotes and heterozygotes; both of which exhibit similarities to specific clinical characteristics of BCIE. Homozygotes suffered from severe skin fragility and died shortly after birth. Heterozygotes were apparently unaffected at birth, but developed hyperkeratosis with age. In both genotypes, aggregation of cytokeratin intermediate filaments, changes in cytokeratin expression, and alterations in the program of epidermal differentiation were observed. In addition we demonstrate, for the first time, the existence of the murine equivalent of human cytokeratin 16.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.