ArticleThe Journal of cell biology1996
Thioredoxin is required for vacuole inheritance in Saccharomyces cerevisiae.
Article in The Journal of cell biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 75 citations in OpenAlex.
- Sec17/Sec18 can support membrane fusion without help from completion of SNARE zippering.eLife · 2021Article
- HOPS recognizes each SNARE, assembling ternaryeLife · 2020Article
- Sec17 (α-SNAP) and Sec18 (NSF) restrict membrane fusion to R-SNAREs, Q-SNAREs, and SM proteins from identical compartments.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Article
- LegC3, an effector protein from Legionella pneumophila, inhibits homotypic yeast vacuole fusion in vivo and in vitro.PloS one · 2013Article
- p21-activated kinases Cla4 and Ste20 regulate vacuole inheritance in Saccharomyces cerevisiae.Eukaryotic cell · 2009Article
- Moonlighting proteins in yeasts.Microbiology and molecular biology reviews : MMBR · 2008Review
- PaTrx1 and PaTrx3, two cytosolic thioredoxins of the filamentous ascomycete Podospora anserina involved in sexual development and cell degeneration.Eukaryotic cell · 2007Article
- Article
- Efficient extraction of thioreodoxin from Saccharomyces cerevisiae by ethanol.Applied and environmental microbiology · 2007Article
- The SNARE Ykt6 mediates protein palmitoylation during an early stage of homotypic vacuole fusion.The EMBO journal · 2004Article
- Vacuole membrane fusion: V0 functions after trans-SNARE pairing and is coupled to the Ca2+-releasing channel.The Journal of cell biology · 2003Article
- A role for Vps1p, actin, and the Myo2p motor in peroxisome abundance and inheritance in Saccharomyces cerevisiae.The Journal of cell biology · 2001Article
- The N-terminal domain of the t-SNARE Vam3p coordinates priming and docking in yeast vacuole fusion.Molecular biology of the cell · 2001Article
- Vac8p release from the SNARE complex and its palmitoylation are coupled and essential for vacuole fusion.The EMBO journal · 2001Article
- A Ypt/Rab effector complex containing the Sec1 homolog Vps33p is required for homotypic vacuole fusion.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- A new role for a SNARE protein as a regulator of the Ypt7/Rab-dependent stage of docking.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- A novel cold-sensitive allele of the rate-limiting enzyme of fatty acid synthesis, acetyl coenzyme A carboxylase, affects the morphology of the yeast vacuole through acylation of Vac8p.Molecular and cellular biology · 2000Article
- Inhibitor of striate conditionally suppresses cell proliferation in variegated maize.Genes & development · 2000Article
- GATE-16, a membrane transport modulator, interacts with NSF and the Golgi v-SNARE GOS-28.The EMBO journal · 2000Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The vacuole of Saccharomyces cerevisiae projects a stream of tubules a and vesicles (a "segregation structure") into the bud in early S phase. We have described an in vitro reaction, requiring physiological temperature, ATP, and cytosol, in which isolated vacuoles form segregation structures and fuse. This in vitro reaction is defective when reaction components are prepared from vac mutants that are defective in this process in vivo, Fractionation of the cytosol reveals at least three components, each of which can support the vacuole fusion reaction, and two stimulatory fractions. Purification of one "low molecular weight activity" (LMA1) yields a heterodimeric protein with a thioredoxin subunit. Most of the thioredoxin of yeast is in this complex rather than the well-studied monomer. A deletion of both S. cerevisiae thioredoxin genes causes a striking vacuole inheritance defect in vivo, establishing a role for thioredoxin as a novel factor in this trafficking reaction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.